2025.2.20 王彦庄研究员（深圳湾实验室）学术报告

Dr. Yanzhuang Wang is currently a Senior Principal Investigator at Shenzhen Bay Laboratory (SZBL). Before that He was a Professor in the Department of Molecular, Cellular, and Developmental Biology and the Department of Neurology at the University of Michigan. He has successfully mentored numerous junior scientists. He has extensive research experience in cell biology, biochemistry, molecular biology, neurobiology, and endocrinology. His research into Golgi biogenesis, function, and defects has led to breakthroughs with implications for diseases such as cancer, diabetes, SARS-CoV-2 infection, and Alzheimer’s. He is passionate about converging research, disease treatment, and drug development. His overarching goal is to leverage his extensive expertise and leadership in innovative research and therapeutic interventions to make a meaningful impact on human health.

Dr. Wang dedicated to innovative research and made significant contributions to the field. He characterized Golgi stacking proteins GRASP55 and GRASP65, unveiling the mechanism and function of Golgi stack formation. He identified GRASP55 as an energy sensor that controls autophagosome maturation in response to cellular stresses. Additionally, He revealed that p97-mediated post-mitotic Golgi membrane fusion is regulated by monoubiquitination. More recently, He has explored the causes of Golgi defects and their effects on human diseases. He has published over 100 peer-reviewed articles, 9 academic monographs, and edited two books.

Abstract

Dr. Wang’s research focuses on Golgi biogenesis, function, and its implications in disease. The Golgi apparatus is a vital cellular membrane organelle within the secretory pathway, responsible for transporting and processing a diverse array of proteins. A distinctive characteristic of this organelle is its stacked arrangement of flattened cisternae, which undergoes rapid disassembly and reassembly under physiological or stress conditions. His research aims to understand how this structure is formed and why its formation is important for Golgi to function under normal and disease conditions. Dr. Wang's research has contributed significantly to our understanding of Golgi dynamics, particularly in diseases such as diabetes, neurodegenerative disorders, SARS-CoV-2 infection, and cancer. In this seminar, Dr. Wang will share his groundbreaking work on Golgi structure formation and function, as well as his recent unpublished findings on Golgi defects in diseases such as Alzheimer’s disease.