H index=26, total citations>4000 (Web of Science, 2017);
                    #Corresponding author; *Co-first authors;


  • Gao L, Wang L, Dai T, Jin K, Zhang Z, et al., Zhou F#, Zhang L#. Tumor-derived exosome antagonize innate antiviral immunity. Nature Immunology. 2018 

  • Yan X#, Zhang L#. A special issue on TGF- signaling: regulation, crosstalk and biology.  Acta Biochim Biophy Sin. 2018

  • Wang S, Xie F, Chu F, Zhang Z, Yang B, Dai T, Gao L, Wang L, Ling L, Jia J, van Dam H, Jin J, Zhang L#, Zhou F#. YAP antagonizes innate antiviral immunity and is targeted for lysosomal degradation through kinase-IKKe mediated phosphorylation. Nature Immunology. 2017 

  • Zhang Z, Fan Y, Xie F, Shao L, et al., Jin J, Ding C, Sheng Y, Zhou F, Zhang L#. Breast cancer metastasis suppressor OTUD1 deubiquitylates SMAD7.  Nature Communications. 2017

  • Xie F, Jin K, Shao L, Fan Y, Tu YF, Yang B, van Dam H, Ten Dijke P, Weng HL, Dooley S, Wang S, Jia JL, Jin J, Zhou F#, Zhang L#. FAF1 phosphorylation by AKT accumulates TGF- type II receptor and drives breast cancer metastasis. Nature Communications. 2017

  • Zhou F, Xie F, Jin K, Zhang ZK, Clerici M, Gao R, Sixma TK, Huang HZ, van Dinther M, Zhang L#, Ten Dijke P#. USP4 inhibits SMAD4 monoubiquitination and promotes activin and BMP signaling. EMBO Journal. 2017

  • Jin K#, Li T, van Dam H, Zhou F#, Zhang L#. Molecular insight into tumor metastasis: tracing the dominant events. Journal of Pathology. 2017 Jan   

  • Xie F, Ling L, van Dam H, Zhou F#, Zhang L#. TGF- signaling in cancer metastasis. Acta Biochim Biophy Sin. 2017 

  • Zhang L#, Xie F, Ten Dijke P,Zhang J,Zhou F#. SUMO-triggered ubiquitination of NR4A1 controls macrophage cell death. Cell Death & Differentiation. 2017 

  • Gao Z, Li Y,Wang F, Huang T, Fan K, Zhang Y, Zhong J, Cao Q, Chao T, Jia J, Yang S, Zhang L, Xiao Y, Zhou J, Feng X, J Jin. Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability.  Nature Communications. 2017

  • Liu K, Xie F, Gao A, Zhang R, Zhang L, Xiao Z, Hu Q, Huang W, Huang Q, Lin B, Zhu J, Wang H, Que J, Lan X. Sox2 regulates multiple malignant processes of breat cancer development through the SOX2/miR-181a-5p, miR-30e-5p/TUSC3 axis. Molecular Cancer 2017 

  • Li Y, Jin K, Gabi W van Pelt, Hans van Dam, Yu X, Wilma E. Mesker, Peter ten Dijke, Zhou F#,  Zhang L#. c-Myb enhances breast cancer invasion and metastasis through Wnt/-catenin/Axin2 pathway. Cancer Res. 2016 

  • Zhou F#, Li F, Fang PF, Dai T, Yang B, van Dam H, Jia jl, Zheng M, Zhang L#. Ubiquitin-specific Protease 4 Antagonize Osteoblast Differentiation through Dishevelled. J Bone Miner Res. 2016 

  • Jin K#, Li T, Sanchez-Duffhues G, Zhou F#, Zhang L#. Involvement of inflammation and its related microRNAs in hepatocellular carcinoma. Oncotarget. 2016 

  • Zhang L, Zhou F, van Dinther M, Ten Dijke P. Determing TGF- Receptor levels in the Cell Membrane Methods Mol Biol. 2016

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).Klionsky DJ, et al., Zhang L, et al., Autophagy. 2016 

  • Li Y, Drabsch Y, Pujuquet P, Ren J, van Laar T, Zhang L, van Dam H, Clement-Lacroix P, Ten Dijke P. Genetic depletion and pharmacological targeting of alphav integrin in breast cancer cells impairs metastasis in zebrafish and mouse xenograft models. Breast Cancer Res. 2015 Feb 25

  • Chen F, Chen J, Lin J, Cheltsov AV, Xu L, Chen Y, Zeng Z, Chen L, Huang M, Hu M, Ye X, Zhou Y, Wang G, Su Y, Zhang L, Zhou F, Zhang XK, Zhou H. NSC-640358 acts as RXR ligand to promote TNF-mediated apoptosis of cancer cell. Protein Cell. 2015 Sep 

  • Xie F, Zhang Z, van Dam H, Zhang L#, Zhou F#. Regulation of TGF- Superfamily Signaling by SMAD Mono-Ubiquitination. Cells. 2014 Oct 

  • Zhou F, Li F, Xie F, Zhang Z, Huang H, Zhang L#. TRAF4 mediates activation of TGF- signaling and is a biomarker for oncogenesis in breast cancer. Sci China Life Sci. 2014 Dec 

  • Zhang J, Zhang X, Xie F, Zhang Z, van Dam H, Zhang L#, Zhou F#. The regulation of TGF-/SMAD signaling by protein deubiquitination. Protein Cell. 2014 Apr 23

  • Zhou F, Drabsch Y, Dekker TJ, de Vinuesa AG, Li Y, Hawinkels LJ,  Sheppard KA, Goumans MJ, Luwor RB, de Vries CJ, Mesker WE, Tollenaar RA,  Devilee P, Lu CX, Zhu H, Zhang L#, Dijke PT#. Nuclear receptor NR4A1  promotes breast cancer invasion and metastasis by activating TGF-  signalling.  Nat Communications. 2014 Mar

  • Zhang L#, Zhou F#, Ten Dijke P#. Signaling interplay between TGF- receptor and PI3K/AKT pathway in cancer. Trends in Biochemical Sciences. 2013 Nov.14


  • Drabsch Y, He S, Zhang L, Snaar-Jagalska BE, Ten Dijke P. Transforming growth factor beta signalling controls human breast cancer metastasis in a zebrafish xenograft model. Breast Cancer Research. 2013 Nov                

  • Zhang L*, Zhou F*, Garca de Vinuesa A, de Kruijf EM, Mesker WE, Hui L, Drabsch Y, Li Y, Bauer A, Rousseau A, Sheppard KA, Mickanin C, Kuppen PJ, Lu CX, Ten Dijke P. TRAF4 Promotes TGF- Receptor Signaling and Drives Breast Cancer Metastasis. Molecular Cell. 2013 Sep                

  • Zhang X, Zhang J, Bauer A, Zhang L, Selinger DW, Lu CX, and ten Dijke P. Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6. EMBO Journal. 2013                 

  • Zhang X, Zhang J, Zhang L, van Dam H, Ten Dijke P. UBE2O negatively regulates TRAF6-mediated NF-B activation by inhibiting TRAF6 polyubiquitination. Cell Research. 2013 

  • Zhang L*, Zhou F*, Drabsch Y, Snaar-Jagalska E, Mickanin C, Huang H, Sheppard KA, Lu C, and ten Dijke P. USP4 is regulated by Akt phosphorylation and directly deubiquitinates TGF-type I receptor. Nature Cell Biology 2012; 

  • Zhang L*#, Huang H*, Zhou F*, Pardo CG, Zhang T, Barakat TS, Sheppard KA, van Dam H, Gribnau J, Lu C, and ten Dijke P#. RNF12 controls embryonic stem cell fate and morphogenesis in zebrafish embryos by targeting Smad7 for degradation. Molecular Cell 2012;

  • Zhou F, Kai Gong, Yandao Gong and Zhang L#. APP intracellular domain (AICD) inhibits Wnt signaling and promotes neurite outgrowth. BBA-Molecular Cell Research 2012;

  • Zhang, J, Zhang X-f, Zhang L, Zhou F, van Dinther M, ten Dijke P. LRP8 mediates Wnt/-catenin signaling and controls osteoblast differentiation. J. Bone Min Res. 2012;                

  • Zhang L, Zhou F, Li Y, Drabsch Y, Zhang J, van Dam H, Ten Dijke P.Fas-associated factor 1 is a scaffold protein that promotes -TrCP mediated -catenin ubiquitination and degradation. J Biol Chem. 2012;                 

  • Gong K, Zhou F, Huang HZ, Gong YD, Zhang L#. Suppression of GSK3 by ERK mediates lipopolysaccharide induced cell migration in macrophage through -catenin signaling. Protein Cell. 2012;              

  • Zhou F*, Zhang L*#, van Laar T, van Dam H, ten Dijke P#. GSK3 inactivation induces apoptosis of leukemia cells by repressing the function of c-Myb. Mol Biol Cell. 2011;

  • Zhou F, Zhang XF, van Dam H, ten Dijke P, Huang HZ#, Zhang L#.Ubiquitin-specific protease 4 mitigates Toll-like/Interleukin-1 receptor signaling and regulates innate immune activation. J Biol Chem. 2012;

  • Zhang L, Shi S, Zhang J, Zhou F, ten Dijke P. Wnt/-catenin signaling changes C2C12 myoblast proliferation and differentiation by inducing Id3 expression. Biochem Biophys Res Commun. 2012:

  • Zhou F, Huang H, Zhang L#. Bisindoylmaleimide I enhances osteogenic differentiation. Protein Cell. 2012; 

  • Guidelines for the use and interpretation of assays for monitoring autophagy. Klionsky DJ, Zhang Let al. Autophagy. 2012;

  • Zhang L, Zhou F, van Laar T, Zhang J, van Dam H, ten Dijke P. Fas-associated factor 1 antagonizes Wnt signaling by promoting -catenin degradation. Mol Biol Cell. 2011;

  • Zhou F, van Laar T, Huang HZ, Zhang L#. APP and APLP1 are degradated through autophagy in response to proteasome inhibition in neuronal cells. Protein Cell. 2011;

  • Zhou F; Gong K; van Laar T; Gong Y, Zhang L#. Wnt/-catenin signal pathway stabilizes APP intracellular domain (AICD) and promotes its transcriptional activity. Biochem Biophys Res Commun. 2011; 


  • Yan X, Zhang J, Pan L, Wang P, Xue H, Zhang L, Gao X, Zhao X, Ning Y, Chen YG TSC-22 promotes TGF--mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity. Mol Cell Biol. 2011;

  • Geng Y, Dong Y, Yu M, Zhang L, Yan X, Sun J, Qiao L, Geng H, Nakajima M, Furuichi T, Ikegawa S, Gao X, Chen YG, Jiang D, Ning W. Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development. Proc Natl Acad Sci USA. 2011; 

  • Zhou F*, Zhang L*, Gong K, Lu G, Sheng B, Wang A, Zhao N, Zhang X, Gong Y. LEF-1 activates the transcription of E2F1. Biochem Biophys Res Commun. 2008; 

  • Zhou F*, Zhang L*, Wang A, Song B, Gong K, Zhang L, Hu M, Zhang X, Zhao N, Gong. The association of GSK3 with E2F1 facilitates nerve growth factor-induced neural cell differentiation. J Biol Chem. 2008; 

  • Gao X, Wen J, Zhang L, Li X, Ning Y, Meng A, Chen YG. Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus. J Biol Chem. 2008;    

  • Su Y*, Zhang L*, Gao X, Meng F, Wen J, Zhou H, Meng A, Chen YG. The evolutionally conserved activity of Dapper2 in antagonizing TGF- signaling. FASEB J. 2007;

  • Chen YG, Wang Z, Ma J, Zhang L, Lu Z. Endofin, a FYVE domain protein, interacts with Smad4 and facilitates transforming growth factor- signaling. J Biol Chem. 2007; 

  • Zhang L, Zhang SP, Gao X, Wen J, Chen YG. Modulation of TGF -signaling in the cytoplasm and the nucleus. Cell Research 16:S131-S157; (Meeting Abstract)

  • Zhang L, Gao X, Wen J, Ning Y, Chen YG. Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation. J Biol Chem. 2006;

  • Gu Y, Jin P, Zhang L, Zhao X, Gao X, Ning Y, Meng A, Chen YG. Functional analysis of mutations in the kinase domain of the TGF- receptor ALK1 reveals different mechanisms for induction of hereditary hemorrhagic telangiectasia. Blood. 2006;

  • Zhang L, Zhou H, Su Y, Sun Z, Zhang H, Zhang L, Zhang Y, Ning Y, Chen YG, Meng A. Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors. Science 2004;