科研课题介绍:

       勇教授实验室目前的研究重心是通过Cul4-DDB1-Roc1泛素连接酶(CRL4)了解哺乳动物发育和发病机制的调控,主要利用分子与细胞生物学的手段研究CRL4靶向的底物,并在小鼠模型中探索其调控的重要性。实验室目前正在研究项目包括

      多发性骨髓瘤MM)的定向治疗以及抗性机制

1.     Double play by cereblon in coordinating effective multiple myeloma (MM) therapy with bortezomib and  immunomodulatory drugs (IMiDs)

2.     Investigation of signaling events critical for the sensitivity and resistance of MM cells to IMiDs

3.    Differential regulation of CD47 turnover in cancer stem cells and cancer cells

肝脏发育和疾病发生机制

1.     Epigeneitc regulation of liver maturation and turnorigenesis

2.     Crosstalks between liver and environmental risk factors in liver diseases

3.     Co-evolving of hepatitis B virus and host defense mechanism

BK离子通道的泛素化调控及其在癫痫和记忆 中的作用

1.     CRL4 targets BK channel transport to suppress epilepsy

2.     Molecular mechanism underlying human nonsydromic mental retardation CRBN mutation in learning and memory