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管坤良博士
浙江大学生命科学研究院共同院长
电话:0571-88206016
Email:
kuguan@ucsd.edu
教育背景
 
1978-1982     杭州大学生物学学士学位
1983-1989     美国普渡大学(Purdue University)生物化学博士
1989-1991     美国普渡大学(Purdue University) 生物化学博士后
工作经历
 
1992-2007     美国密歇根大学(University of Michigan)生物化学系助理教授、副教授、教授
2002-2007     美国密歇根大学(University of Michigan)生命科学研究院Halvor Christensen 教授
2007-至今     美国加州大学圣地亚哥分校(UCSD)药学系教授
学术奖项与活动
 
1989                            The Arnold Kent Balls Award, Department of  Biochemistry, Purdue University
1998-2003                   MacArthur Fellow, The John D. Catherine T. MacArthur Foundation
1999                            Schering-Plough Award (Young Investigator Award), American Society of Biochemistry and Molecular Biology
1999                            Yong Investigator Award, Society of Chinese Bioscientist Association
April 1999                   Procter & Gamble Lecture, Purdue University
April 2004                   Susan Swerling Lecture, Dana-Farber Cancer Institute, Harvard Medical School
2004                            Faculty Recognition Award, University of Michigan
2006                            Distinguished Alumni Award, Purdue University Agriculture School
1995-1999                   Panel member of the NSF cell biology study section
1997-2002                   Editorial board member, Journal of Biological Chemistry
1999-2002                   Editorial board member, Biological Signals and Receptors
2005-                           Editorial board member, Experimental & Mol. Medicine
1998                            NIH Study Section, Molecular Biology (Ad Hoc)
1999-2003                   NIH Study Section, CDF-3
2003-2006                 
中国国家自然科学基金委员会 评审委员
研究方向
 
细胞生长调节及肿瘤细胞生物学的信号转导研究
Signal transduction in cell growth regulation and cancer cell biology
代表性论文(研究论文)
 
Zhao, B., Li, L., Wang, C-Y, and Guan, K-L. (2010) A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCFb-TRCP, Genes & Dev. 24, 72-85.
Li, Z., Zhao, B., Wang, P., Chen, F., Dong, Z., Yang, H., Guan, K-L., and Xu, Y. (2010) Structural insights into the YAP and TEAD complex. Genes & Dev. 24, 235-240.
Zhao, S., Xu, W., Jiang, W., Yu, W., Lin, Y., Zhang, T., Yao, J., Zeng, Y., Li, H., Li, Y., Shi., J., An, W., Hancock, S.M., He., F., Qin, L., Chin, J., Yang, P., Chen, X., Lei, Q., Xiong, Y., Guan, K-L., (2010) Regulation of cellular metabolism by protein lysine acetylation. Science 327, 1000-1004.
Liang I., Kim, J., Okazawa, H., Zhao, J., Zhao, B., Yu, J., Chinnaiyan, A., Israel, M., Goldstein, L., Abujarour, R., Ding, S., and Guan, K-L. (2010). The role of YAP transcription co-activator in regulating stem cells self-renewal and differentiation. Genes & Dev. 24, 1106-1118.
Li, L., Kim, E., Yuan, H., Inoki, K., Goraksha-Hicks, Schiesher, R. L., Neufeld, T.P., Guan, K-L., (2010) Regulation of mTORC1 by the Rab and ARF GTPases. J. Biol. Chem. 285, 19705-9.
Guan, K-L., Yu, W., Lin, Y., Xiong, Y., Zhao, S. (2010) Generation of acetyllysine antibodies and affinity enrichment of acetylated peptides. Nature Protocol 5, 1583-1595.  
Liu, C-Y, Zha, ZY., Zhang, H., Zhou, X., Huang, W., Zhao, D., Chan, S.W., Lim, C.J., Hong, W., Zhao, S., Xiong, Y., Lei, QY, and Guan, K-L. (2010) The Hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCFβ-TrCP E3 ligase.  J. Biol. Chem. 285, 37159-69.
Kang, Y.J., Lu, M-K., and Guan, K-L. (2011) The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis. Cell Death & Differentiation. 18, 133-44.
Zhao, B., Li, L, Lu, O., Wang, L.H., Liu, C., Lei, Q., and Guan, K-L. (2011) Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. Genes & Dev. 25, 51-63.
Xu, W., Yang, H., Liu, Y., et al, Guan, K-L., Zhao, S., and Xiong Y. (2011). Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of -ketoglutarate-dependent dioxygenases. Cancer Cell 19, 17-30.
Liu, C., Lv X., Li, T., Xu, Y., Zhou, X., Zhao, S., Xiong, Y., Lei, Q., and Guan, K-L., (2011). PP1 Cooperates with ASPP2 to dephosphorylate and activate TAZ. J. Biol. Chem. 286, 5558-66.
Kim, J., Kundu, M., Viollet, B., and Guan K-L., (2011) AMPK and mTOR regulate autophagy via direct phosphorylation of ULK1. Nature Cell Biol. 13, 132-141.
Inoki, K., Mori, H., Wang, J., Suzuki, T., Hong, S., Yoshida, S., Blattner. S.M., Ikenoue, T., Rüegg, R.A., Hall, M.N., Kwiatkowski, D.J., Rastaldi, M.P., Huber , T.B., Kretzler, M., Holzman, L.B., Wiggins, R.C., Guan, K-L. (2011). mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy. J. Clin. Invest. 121, 181-196.
Xie, X., Zhang, D., Zhao, B., Lu, M-K., You, M., Condorelli, G., Wang, C.Y., and Guan, K-L. (2011) IKKε and TBK1 activate AKT by direct phosphorylation. Proc. Natl. Acad. Sci. 108, 6474-9.
Jiang, W., Wang, S., Xiao, M., Lin, Y., Lei, Q.Y., Xiong, Y., Guan, K-L., and Zhao, S. (2011). Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase. Mol. Cell 43, 33-44.
Lv, L., Li, D., Zhao, D., Lin, R., Chu, Y., Zhang, H., Zha., Z., Xu, Y., Li, Z., Wang, G., Huang, Y., Zhao, S., Xiong, Y., Guan, K-L., Lei, Q-Y. (2011) Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth. Mol. Cell, 42, 719-30.
Gong, R., Li., L., Liu, Y., Wang, P., Yang, H., Wang, L., Cheng, J., Guan, K-L., and Xu, Y. (2011) Crystal Structure of Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation. Genes & Dev. 25, 1668-73.
Zhao, B., Li, L., Wang, L., Wang, C.Y., Yu, J., and Guan, K-L. (2012) Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis and inhibit tumor metastasis. Genes & Dev. 26, 54-68.
Zhang, T., Wang, S., Lin, Y., Ye, D., Xiong, Y., Zhao, S., Guan, K-L. (2012) Acetylation negatively regulates glycogen phosphorylase by recruiting protein phosphatase 1. Cell Metabolism 15, 75-87.
Xiao, M., Yang, H., Xu, W., et al, Xiong, Y., and Guan, K-L.  (2012) Inhibition of -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes & Development 26, 1326-38.
Huang, W., Lv, X., Liu, C., Zha, Z., Zhang, H., Jiang, Y., Xiong, Y., Lei, Q., and Guan, K-L. (2012) The N-terminal phosphodegron targets TAZ for SCFβ-TrCP dependent degradation in response to PI3K inhibition. J. Biol. Chem. 287, 26245-53.
Yu, F-X., Zhao, B., Panupinthu, N., Jewell, J. L., Wang, L., Zhao, J., Yan, H., Tumaneng, K., Li, H., Fu, X-D., Mills, G. B., and Guan, K-L. (2012) Regulation of the Hippo-YAP pathway by G-protein coupled receptor signaling. Cell 150, 780-91.
Mo, J.S., Yu, F-X., Gong, R., Brown, J.H., and Guan, K-L. (2012) Regulation of the Hippo-YAP pathway by protease activated receptor PAR. Genes & Dev. 26, 2138-2143.
Tumaneng, K., Schlegelmilch, K., Russell, R.C., Yimlamai, D., Basnet, H., Mahadevan, N., Fitamant, J., Bardeesy, N., Camargo, F., and Guan, K-L. (2012) YAP mediates crosstalk between the Hippo and PI3K-TOR pathways by suppressing PTEN via miR-29. Nature Cell Biol. 14, 1322-1329.
Kim, J., Kim, Y.C., Fang, C., Russell, R.C., Kim, J.H., Fan, W., Liu, R., Zhong, Q., and Guan, K-L. (2013) Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell 152, 290-303.
Li, L. and Guan, K-L. (2013) Microtubule-associated protein/microtubule affinity-regulating kinase 4 (MARK4) is a negative regulator of the mammalian target of rapamycin complex 1 (mTORC1). J. Biol. Chem. 288, 703-708.
Zhao, D., Zou, S-W., Liu, Y., Zou, X., Mo, Y., Wang, P., Xu, Y-H., Dong, B., Xiong, Y., Lei, Q-Y., and Guan, K-L. (2013) Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer. Cancer Cell, 23, 464-476.
Russell, R.C., Tian, Y., Yuan, H., Park, H.W., Chang, Y.Y., Kim, J., Jim, H., Neufeld, T., Dillin, A., Guan, K-L. (2013) ULK1 induces autophagy by phosphorylating Beclin-1 and activating Vps34 lipid kinase. Nature Cell Biol. 15, 741-50.
Yuan, H.X., Russell, R., and Guan, K-L. (2013) Regulation of PIK3C3/VPS34 complexes by mTOR in nutrient stress-induced autophagy. Autophagy. 12, 1983-95.
Yu, F-X., Zhang, Y., Park, H.W., Jewell, J.L., Chen, Q., Pan, DJ., Taylor, S.S., Lai, Z-C., and Guan, K-L. (2013) Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation. Genes & Dev. 27, 1223-32.
Lin, R., Xue, R/T., Gao, X., Li., T., Zhou, X., Guan, K-L., Xiong Y., and Lei, Q-Y. (2013) Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth. Mol. Cell 51, 506-518.
Lv, L., Xu, Y., Zhao, D., Li, F., Wang, W., Sasaki, N., Jiang, Y., Zhou, X., Li, T., Guan, K-L., Lei, Q., Xiong, Y. (2013) Mitogenic and oncogenic signals stimulate K433 acetylation to promote PKM2 protein kinase activity and nuclear localization. Mol. Cell 52, 340-352.
Li, J., Chen, X., Ding, X., Cheng, Y., Zhao, B., Lai, Z.C., Al Hezaimi, K., Hakem, R., Guan, K-L., Wang, C. Y. (2103) LATS2 suppressed oncogenic Wnt signaling by disrupting b-catenin/BCL9 interaction. Cell Rep. 5, 1650-63.
Tang, H., Inoki, K., Lee, M., Wright, M., Khuong, A., Sugiarto, A., Garner, M., Oaik, J., Dpinho, R., Goldman, R., Guan, K-L., Shrager, J. B. (2014) Denervation Muscle Atrophy is Promoted by mTORC1 via Activating FoxO and E3 Ubiquitin Ligases. Science Signaling 7, ra18, 1-10.
Yu, FX., Luo, J., Mo, J-S., Liu, G., Kim, Y.C., Meng, Z., Zhao, L., Peyman, G., Ouyang, H., Jiang, W., Zhao, J., Chen, X., Zhang, L., Bastian, B.C., Zhang, K. and Guan, K-L. (2014) Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP. Cancer Cell 25, 822-830.
Kim, Y.C., Park, H.W., Sciarretta, S., Mo, J.S., Jewell, J.L., Russell, R.C., Wu, X., Sadoshima, J., and Guan, K-L. (2014) Essential role of Rag GTPases in heart by regulating lysosomal function. Nature Comm. 5, 4241-14.
Wang, Y.P., Zhou, L.S., Zhao, Y.Z., Wang, S.W., Chen, L.L., Liu, L.X., Ling, Z.Q., Hu, F.J., Sun, Y.P., Zhang, J.Y., Yang, C., Yang, Y., Xiong, Y., Guan, K-L., and Ye, D. (2014) Regulation of G6PD acetylation by KAT9/SIRT2 modulates NADPH homeostasis and cell survival during oxidative stress. EMBO J. 33, 1304-20.
Zhao, D., Mo, Y., Li, M.T., Zhou, S.W., Cheng, Z.L., Xiong, Y., Guan, K-L., and Lei, Q.Y. (2014) Notch-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells. J. Clin. Investigation. 124, 5453-65.
Liu, G., Yu, F.X., Kim, Y.C., Meng, Z., Naipauer, J., Looney, D.J., Liu, X., Gutkind, J.S., Mesri, E.A., and Guan, K-L. (2015) Kaposi sarcoma-associated herpesvirus promotes tumorigenesis by modulating the Hippo pathway. Oncogene, 34, 3536-46.
Jewell, J.L., Kim, Y.C., Russell, R.C., Yu, F.X., Park, H.W., Plouffe, S.W., Tagliabracci, V.S., and Guan, K-L. (2015) Differential Regulation of mTORC1 by Leucine and Glutamine. Science 347, 194-198.
Wang, Y., Xiao, M., Chen, X., Xu, Y., Chen, L., Wang, P., Yang, H., Ma, S., Jiang, B., Ye, D., Guan, K-L., and Xiong, Y. (2015). WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation. Mol. Cell, 57, 1-12.
Mo, J.S., Meng, Z., Kim, Y.C., Park, H.W., Hansen C.G., Kim, S., Lim, D.S, and Guan, K-L. (2015) AMPK mediates cellular energy stress to regulate YAP and the Hippo pathway. Nature Cell Biol. 17, 500-10.
Taniguchi, K., Wu, L-W., Grivennikov, S.I., de Jong, P.R., Lian, I., Yu, F-X., Wang, K., Ho, S.B., Boland, B.S., Chang, J.T., Sandborn, W.J., Hardiman, G., Raz, E., Maehara, Y., Yoshimura, A., Zucman-Rossi, J., Guan, K-L., and Karin, M. (2015). A gp130-Src-YAP Module Links Intestinal Injury and Inflammation to Epithelial Regeneration. Nature 519, 57-62.
Ma, S., Jiang, B., Deng, W., Gu, Z-K., Wu, F.-Z., Li, T., Xia, Y., Yang, H., Ye., D., Xiong, Y., and Guan, K-L. (2015). 2-Hydroxyglutate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growth. Oncotarge 6, 8606-20.
Zhou , X., Wang, S., Wang, Z., Feng, X., Liu, P., Lv., X., Li, F., Yu, F.X., Sun, Y., Yuan, H., Zhu, H., Xiong, Y., Lei, Q.Y., and Guan, K-L. (2015) Estrogen regulates Hippo signaling via GPER in breast cancer. J. Clin. Invest. 125, 2123-35.
Zha, Z., Han, X., Smith, M.D., Liu, Y., Giguere, P.M., Kopanja, D., Raychaudhuri, P., Siderovski, D.P., Guan, K-L., Lei, Q-YY., Xiong, Y. (2015) A non-canonical function of Gβ as a subunit of E3 ligase in targeting GRK2 ubiquitylation . Mol. Cell 58, 794-803.
Qi, Q., Li. D.Y., Luo, H.R., Guan, K-L., and Ye, K. (2015) Netrin-1 exerts oncogenic activities through enhancing YAP stability. Proc. Natl. Acad. Sci. 112, 7255-60.
Lv, X., Liu, C.Y., Wang, Z., Sun, Y.P., Xiong, Y., Lei, Q.Y., and Guan, K-L. (2015) PARD3 Induces TAZ Activation and Cell Growth by Promoting LATS1 and PP1 Interaction. EMBO Rep. 16, 975-85.
Gong, R., Yu, F-X., Hong, A.W., Plouffer, S.W., Zhao, B., Liu, G., Xu, Y., Guan, K-L. (2015) Opposing roles of conventional and novel PKC in the Hippo-YAP pathway regulation. Cell Res. 25, 985-8.
Park, H. W., Kim, Y.C., Yu, B., Moroishi, T., Mo, J-S., Plouffe, S.W., Meng, Z., Lin, K.C., Yu, F.X., Alexander, C.M., Wang, C., and Guan, K-L. (2015) Alternative Wnt Signaling Activates YAP/TAZ . Cell 162, 780-794.
Toshiro, M., Park, H.W., Qin, B., Chen, Q., Meng, Z., Plouffe, S.W., Taniguchi, K., Yu, F.X., Karin, M., Pan, D., and Guan, K-L. (2015) A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis. Genes & Dev. 29, 1271-84.
Wang, S., Jiang, B., Zhang, T., Liu, L., Wang, Y., Wang, Y.P., Chen, X., Lin, H., Zhou, L., Chen, L., Yang, C., Xiong, Y., Ye., D., and Guan, K-L. (2015) Regulation of PGK1 Acetylation by Insulin and mTOR Pathway Modulates Glycolytic ATP Production and Cellular Redox Potential. PLOS Biology 13, e1002243.
Meng, Z., Moroishi, T., Mottier-Pavie, V., Plouffe, S.W., Hansen, C.G., Hong, A.W., Park, H.W., Mo, J-S., Lu, W., Lu, S., Flores, F., Yu, F-X., Halder, G., Guan, K-L. (2015). MAP4K Family Kinases Act in Parallel to MST1/2 to Activate LATS1/2 in the Hippo Pathway. Nature Commun. 6, 8357.
Ma, T., Li, J., Xu, Y., Yu, C., Xu, T., Wang, H., Liu, K., Cao, N., Nie, B-M., Zhu, S., Xu, S., Li, K., Wei, W-G., Guan, K-L., and Ding, S. (2015) Atg5-independent autophagy regulates mitochondrial clearance and is essential for iPSC reprogramming. Nature Cell Biol. 17, 1379-87.
Yuan, H.X., Wang, Z., Yu, F-X., Li, F., Russell, RC, Jewell, J.L., Guan, K-L. (2015) NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition.Genes & Dev. 29, 2362-76.
Hansen, C.G., Ng, Y.L.D., Lam, W.M., Plouffe, S.L., and Guan, K-L.(2015) The Hippo pathway effector YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1. Cell Res. 25, 1299-313.
Feng, X, Liu, P, Zhou, X, Li, M.T, Li, F.L, Wang, Z, Meng, Z.P, Sun, Y.P, Yu, Y, Xiong, Y, Yuan, H.X, Guan, K-L. (2016) Thromboxane A2 activates YAP/TAZ to induce vascular smooth cell proliferation and migration. J. Biol. Chem. 291, 18947-58.
Plouffe, S.W., Meng, Z., Lin, K.C., Lin, B., Hong, A.W., Chun, J.V., and Guan, K-L. (2016) Characterization of Hippo pathway components by gene inactivation. Mol. Cell 64, 993-08.
Moroishi, T., Hayashi, T., Pan, W., Fujita, Y., Holt, M.V., Qin, J., Carson, D.A., and Guan, K-L.(2016) The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity. Cell 167, 1525-39.
代表性论文(综述)
 
Zhao, B., Li, L., Lei, Q., and Guan, K-L. (2010) The Hippo-YAP pathway in organ size control and tumorigenesis. Genes & Dev. 24. 862-874.
Zhao, B., Li L, and Guan, K-L. (2010) Hippo signaling at a glance. J. Cell Sci. 123, 4001-6. 
Guan, K-L. and Xiong, Y. (2011) Regulation of intermediate metabolism by protein acetylation. TIBS 36, 108-116.
Kim, J. and Guan, K-L. (2011) Amino acid signaling in mTOR activation. Ann. Rev. Biochem. 80, 1001-32.
Zhao, B., Tumaneng, K., and Guan, K-L. (2011) The Hippo tumor suppressor pathway in organ size control, tissue regeneration and stem cell self-renewal. Nature Cell Biol. 13, 877-83.
Russell, R.C. Fang, C., and Guan, K-L. (2011) An emerging role for TOR signaling in mammalian tissue and stem cell physiology. Development, 138, 3343-56.
Inoki, K. Kim, J., and Guan, K-L. (2011) AMPK and mTOR in cellular energy homeostasis and drug targets. Ann. Rev. Pharmacol. Toxicol. 52, 381-400.
Tumaneng, K., Russell, R. C., and Guan, K-L. (2012) Organ size control the Hippo and TOR pathways. Current Biology 22, R368-R379.
Hong, W. and Guan, K-L., (2012) The YAP and TAZ transcription coactivators: key downstream effectors of the mammalian Hippo pathway. Seminar in Cell Dev. Biol. 23, 785-93.
Xiong, Y. and Guan, K-L. (2012) Mechanistic insights into the regulation of metabolic enzymes by acetylation. J. Cell Biol. 198, 155-64.
Yuan, H-X., Xiong, Y., and Guan, K-L. (2013) Nutrient sensing, metabolism, and cell growth control. Mol. Cell. 49, 379-387.
Jewell, J.L. and Guan, K-L. (2013) Nutrient signaling to mTOR and cell growth. TIBS. 38, 233-242.
Yu, F. and Guan, K-L. (2013) The Hippo Pathway: Regulators and Regulations. Genes & Dev. 27, 355-371.
Jewell, J.L. Russell, R.C., and Guan, K-L. (2013) Amino acid signaling upstream of mTOR. Nature Rev. Mol. Cell. Biol. 14, 133-139.
Park, H.W. and Guan, K-L. (20313) Regulation of the Hippo pathway and implications for anticancer drug development. Trends in Pharmacol. Sci. 34, 581-589.
Russell, R.C., Yuan, H., Guan, K-L. (2014) Autophagy regulation by nutrient signaling. Cell Res. 24, 42-57.
Mo, J-S., Park, H.W., and Guan, K-L. (2014) The Hippo signaling pathway in stem cell biology and cancer. EMBO Rep. 15, 642-656.
Kim, Y.C., Park, H.W., and Guan, K-L. (2015) mTOR: a pharmacological target for autophagy regulation. J. Clinical Investigation. 125, 25-32.
Yu, F., Meng, Z., Pflouffe, S., and Guan, K-L. (2015). Hippo pathway in regulation of gastrointestinal tissues. Ann Rev. Physiol. 77, 201-27.
Moroishi, T., Hansen, C., and Guan, K-L. (2015). The Hippo pathway in human cancer. Nature Rev. Cancer. 15, 73-9.
Plouffe, S.W., Hong, A.W., and Guan, K-L. (2015). Diseases implication of the Hippo/YAP pathway. Trends in Mol. Medicine. 21, 212-222.
Zhou, Q., Li, L., Zhao, B., and Guan, K-L. (2015) The Hippo pathway in heart development, regeneration, and diseases. Circulation Res. 116, 1431-1447.
Hansen, C., Moroishi, T., and Guan, K-L. (2015) YAP and TAZ: A nexus for Hippo signaling and beyond. Trends in Cell Bio. 25, 499-513.
Yu, F.X., Zhao, B., and Guan, K-L. (2015) Hippo pathway in organ size control, tissue homeostasis, and cancer.Cell 163, 811-828.
Meng, Z., Moroishi, T., and Guan, K-L. (2016). Mechanisms of the Hippo pathway regulation. Genes & Dev. 30, 1-17.
Hong, A.W., Meng, Z., Guan, K-L. (2016). The Hippo Pathway in Intestinal Regeneration and Disease. Nat. Rev. Gastroenterol.&Hepatol. 13, 324-37.