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发表论文

·Yu C, Fan X, Sha Q Q, Wang H H, Li B T, Dai X X, Shen L, Liu J, Wang L, Liu K, Tang F, Fan H Y. (2017). CFP1 Regulates Histone H3K4 Trimethylation and Developmental Potential in Mouse Oocytes. Cell Rep, 20(5): 1161-1172.7f0e1dc87b3336f50ad465c30d94085f.png

·Liu S, Chen S, Li X, Wu S, Zhang Q, Jin Q, Hu L, Zhou R, Yu Z, Meng F, Wang S, Huang Y, Ye S, Shen L, Xia Z, Zou J, Feng X H, Xu P. (2017). Lck/Hck/Fgr-Mediated Tyrosine Phosphorylation Negatively Regulates TBK1 to Restrain Innate Antiviral Responses. Cell Host Microbe21(6): 754-768.7f0e1dc87b3336f50ad465c30d94085f.png

·Guo A, Huang S, Yu J, Wang H, Li H, Pei G, Shen L. (2017). Single-Cell Dynamic Analysis of Mitosis in Haploid Embryonic Stem Cells Shows the Prolonged Metaphase and Its Association with Self-diploidization. Stem Cell Reports 8(5): 1124-1134.7f0e1dc87b3336f50ad465c30d94085f.png

·Gao, L., Guan, W., Wang, M., Wang, H., Yu, J., Liu, Q., Qiu, B., Yu, Y., Ping, Y., Bian, X., Shen, L., & Pei, G. (2017). Direct Generation of Human Neuronal Cells from Adult Astrocytes by Small Molecules. Stem Cell Reports7f0e1dc87b3336f50ad465c30d94085f.png

·Guo, G., Pinello, L., Han, X., Lai, S., Shen, L., Lin, T. W., Zou, K., Yuan, G. C., & Orkin, S. H. (2016). Serum-Based Culture Conditions Provoke Gene Expression Variability in Mouse Embryonic Stem Cells as Revealed by Single-Cell Analysis. Cell Rep14,956-9657f0e1dc87b3336f50ad465c30d94085f.png

·Inoue, A., Shen, L., Matoba, S., & Zhang, Y. (2015). Haploinsufficiency, but not defective paternal 5mC oxidation, accounts for the developmental defects of maternal Tet3 knockouts. Cell Rep10: 463-470.7f0e1dc87b3336f50ad465c30d94085f.png

·Matoba, S., Liu, Y., Lu, F., Iwabuchi, K.A., Shen, L., Inoue, A., and Zhang, Y. (2014). Embryonic Development following Somatic Cell Nuclear Transfer Impeded by Persisting Histone Methylation. Cell 159, 884–895.7f0e1dc87b3336f50ad465c30d94085f.png

·Wu, H., Wu, X., Shen, L., and Zhang, Y. (2014). Single-base resolution analysis of active DNA demethylation using methylase-assisted bisulfite sequencing. Nat Biotechnol. 32, 1231–1240.7f0e1dc87b3336f50ad465c30d94085f.png  

·Shen, L.*, Inoue, A.*, He, J., Liu, Y., Lu, F., and Zhang Y. (2014). Tet3 and DNA Replication Mediate Demethylation of Both the Maternal and Paternal Genomes in Mouse Zygotes. Cell Stem Cell 15, 459–470.7f0e1dc87b3336f50ad465c30d94085f.png

·Shen, L.*, Song, C.X.*, He, C., Zhang, Y. (2014). Mechanism and Function of Oxidative Reversal of DNA and RNA Methylation. Annu Rev Biochem 83, 585-614.7f0e1dc87b3336f50ad465c30d94085f.png

·Yamaguchi, S., Shen, L., Liu, Y., Sendler, D., and Zhang, Y. (2013). Role of Tet1 in genomic imprinting erasure. Nature 504, 460-464.7f0e1dc87b3336f50ad465c30d94085f.png

·Lin, F., Shen, L., Jang, C., Falnes, P., and Zhang, Y. (2013) Ikbkap/Elp1 deficiency causes male infertility by disrupting meiotic progression. PLoS Genet 9, e1003516. 7f0e1dc87b3336f50ad465c30d94085f.png

·Shen, L.*, Wu, H.*, Diep, D., Yamaguchi, S., D'Alessio, A., Fung, H., Zhang, K., and Zhang, Y. (2013). Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics. Cell 153, 692-7067f0e1dc87b3336f50ad465c30d94085f.png

·Shen, L., Zhang, Y. (2013). 5-Hydroxymethylcytosine: generation, fate, and genomic distribution. Current Opinion in Cell Biology 25, 289–296.7f0e1dc87b3336f50ad465c30d94085f.png

·He, J., Shen, L., Wan, M., Taranova, O., Wu, H., and Zhang, Y. (2013). Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes. Nat Cell Biol 15, 373–384.7f0e1dc87b3336f50ad465c30d94085f.png

·Yamaguchi, S., Hong, K., Liu, R., Inoue, A., Shen, L., Zhang, K., and Zhang, Y. (2013). Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during germ cell reprogramming. Cell Res 23, 329-339.7f0e1dc87b3336f50ad465c30d94085f.png

·Yamaguchi, S.*, Hong, K.*, Liu, R.*, Shen, L., Inoue, A., Deip, D., Zhang, K., and Zhang, Y. (2012). Tet1 controls meiosis by regulating meiotic gene expression. Nature 492, 443–447.  7f0e1dc87b3336f50ad465c30d94085f.png

· Nabel, C., Jia, H., Ye, Y., Shen, L., Goldschmidt, H., Stivers, J., Zhang, Y., Kohli, R. (2012) AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation. Nat ChemBiol 14(5):457-66.7f0e1dc87b3336f50ad465c30d94085f.png

·Shen, L., Zhang, Y. (2012) Enzymatic Analysis of the Tet proteins. Methods Enzymol 512, 93-105.7f0e1dc87b3336f50ad465c30d94085f.png

·Inoue, A., Shen, L., Dai, Q., He, C., and Zhang, Y. (2011). Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development. Cell Res 21, 1670-1676.7f0e1dc87b3336f50ad465c30d94085f.png

· Ito, S.*, Shen, L.*, Dai, Q., Wu, S.C., Collins, L.B., Swenberg, J.A., He, C., and Zhang, Y. (2011). Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science 333, 1300-1303.7f0e1dc87b3336f50ad465c30d94085f.png

·Chen, T.*, Shen, L.*, Yu, J.*, Wan, H.*, Guo, A., Chen, J., Long, Y., Zhao, J., and Pei, G. (2011). Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells. Aging Cell10, 908-911.7f0e1dc87b3336f50ad465c30d94085f.png

·Shen, L., Gao, G., Zhang, Y., Zhang, H., Ye, Z., Huang, S., Huang, J., and Kang, J. (2010). A single amino acid substitution confers enhanced methylation activity of mammalian Dnmt3b on chromatin DNA. Nucleic Acids Res 38, 6054-6064.7f0e1dc87b3336f50ad465c30d94085f.png

·Zou, L.*, Wang, Z.*, Shen, L., Bao, G.B., Wang, T., Kang, J.H., and Pei, G. (2007). Receptor tyrosine kinases positively regulate BACE activity and Amyloid-beta production through enhancing BACE internalization. Cell Res 17, 389-401.7f0e1dc87b3336f50ad465c30d94085f.png

·Yu, Y.X., Shen, L., Xia, P., Tang, Y.W., Bao, L., and Pei, G. (2006). Syntaxin 1A promotes the endocytic sorting of EAAC1 leading to inhibition of glutamate transport. J Cell Sci 119, 3776-3787.7f0e1dc87b3336f50ad465c30d94085f.png

·Xu, N.J.*, Yu, Y.X.*, Zhu, J.M., Liu, H., Shen, L., Zeng, R., Zhang, X., and Pei, G. (2004). Inhibition of SNAP-25 phosphorylation at Ser187 is involved in chronic morphine-induced down-regulation of SNARE complex formation. J BiolChem279, 40601-40608.7f0e1dc87b3336f50ad465c30d94085f.png