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Selected publications:
  • Fang D*, Gan H*, Cheng L, Lee J, Zhou H, Sarkaria J, Daniels D, Zhang Z#. H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers. eLife, 2018, 7:e36696.
  • Fang D, Gan H, Wang H, Zhou H, Zhang Z#. Probe the function of histone lysine 36 methylation using histone H3 lysine 36 to methionine mutant transgene in mammalian cells. Cell Cycle, 2017, 16(19): 1781-1789.
  • Fang D*, Gan H*, Lee J*, Han J*, Wang Z*, Riester S, Jin L, Chen J, Zhou H, Wang J, Zhang H, Yang N, Bradley E, Ho T, Rubin B, Bridge J, Thibodeau S, Ordog T, Chen Y, Wijnen A, Oliveira A, Xu R, Westerdorf J, Zhang Z#. The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas. Science, 2016, 352(6291): 1344-1348.
  • Hashizume R#, Andor N, Ihara Y, Lerner R, Gan H, Chen X, Fang D, Huang X, Tom MW, Ngo V, Solomon D, Mueller S, Paris PL, Zhang Z, Petritsch C, Gupta N, Waldman TA, James CD. Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma. Nature Medicine, 2014, doi:10.1038/nm.3716
  • Pan C, Fang D, Xu G, Liang J, Zhang G, Wang H, Xie L#, Zhang R#. A novel acidic matrix protein, PfN44, stabilizes magnesium calcite to inhibit the crystallization of aragonite. Journal of Biological Chemistry, 2014: 289(5), 2776-87.
  • Chan KM*, Han J*, Fang D*, Gan H, Zhang Z#. A lesson learned from the H3.3K27M mutation found in pediatric glioma: A new approach to the study of the function of histone modifications in vivo. Cell Cycle, 2013:12:2546 – 2552.
  • Chan KM*, Fang D*, Gan H, Hashizume R, Yu C, Schroeder M, Gupta N, Mueller S, James CD, Jenkins R, Sarkaria J, Zhang Z#. The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression. Genes and Development, 2013, 27(9):985-990.
  • Fang D, Pan C, Lin HJ, Lin Y, Zhang GY, Wang HZ, He MX, Xie LP#, Zhang RQ#. Novel Basic Protein, PfN23, Functions as a Key Macromolecule during Nacre Formation. Journal of Biological Chemistry, 2012: 287(19), 15776–15785.
  • Fang D, Pan C, Lin HJ, Lin Y, Xu GR, Zhang GY, Wang HZ, Xie LP#, Zhang RQ#. Ubiquitylation Functions in the Calcium Carbonate Biomineralization in the Extracellular Matrix. PLOS ONE, 2012: 7(4): e35715.
  • Fang D, Xu GR, Hu YL, Pan C, Xie LP#, Zhang, RQ#. Identification of genes directly involved in shell formation and their functions in pearl oyster, Pinctadafucata. PLOS ONE, 2011: 6(7): e21860.
  • Fang D, Wang H, Zhang Z. (2018) Probing the Function of Oncohistones Using Mutant Transgenes and Knock-In Mutations. In: Orsi G, Almouzni G. (eds) Histone Variants. Methods in Molecular Biology, vol 1832. Humana Press, New York, NY
  • *co-first author, #correspondence author