Yi-Tao Yu, Ph.D.
Professor, Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester Medical Center
Professor, Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester Medical Center
Education
Ph.D. in Molecular Biology, 1989-1994, Case Western Reserve University, School of Medicine, Cleveland, Ohio
M.S. in Neurobiology, 1984-1988, Shanghai Institute of Physiology, Chinese Academy of Sciences, Shanghai, China
B.S. in Chemistry, 1978-1982, Fudan University, Shanghai, China
Ph.D. in Molecular Biology, 1989-1994, Case Western Reserve University, School of Medicine, Cleveland, Ohio
M.S. in Neurobiology, 1984-1988, Shanghai Institute of Physiology, Chinese Academy of Sciences, Shanghai, China
B.S. in Chemistry, 1978-1982, Fudan University, Shanghai, China
Doctoral and Postdoctoral Research
Postdoctoral Research with Joan A. Steitz at Yale University School of Medicine / HHMI, New Haven, Connecticut, March 1, 1995-1999
Mechanism of pre-mRNA splicing, spliceosomal snRNA modification.
Postdoctoral Research with Joan A. Steitz at Yale University School of Medicine / HHMI, New Haven, Connecticut, March 1, 1995-1999
Mechanism of pre-mRNA splicing, spliceosomal snRNA modification.
Doctoral and postdoctoral Research with Timothy W. Nilsen at Case Western Reserve University, Cleveland, Ohio, Jan. 1, 1989-Feb. 28,1995
Spliced Leader (SL) RNA and U6 snRNA sequence requirements for nematode trans-splicing
Spliced Leader (SL) RNA and U6 snRNA sequence requirements for nematode trans-splicing
Journal Editorial Board
Frontiers Journals Series (Frontiers in Non-Coding RNA)
Frontiers Journals Series (Frontiers in Non-Coding RNA)
Journal Reviews
Nature; Nature Chemical Biology; Nature Reviews Genetics; Cell; Molecular Cell; EMBO Journal; Genes & Dev.; Molecular and Cellular Biology; Molecular Biology of the Cell; PNAS; RNA; Nucleic Acids Research; Journal of Biological Chemistry; Journal of Molecular Biology; Molecular Microbiology; Human Molecular Genetics; Accounts of Chemical Research; PLoS ONE, Biochemistry; Frontiers in Non-Coding RNA...
Nature; Nature Chemical Biology; Nature Reviews Genetics; Cell; Molecular Cell; EMBO Journal; Genes & Dev.; Molecular and Cellular Biology; Molecular Biology of the Cell; PNAS; RNA; Nucleic Acids Research; Journal of Biological Chemistry; Journal of Molecular Biology; Molecular Microbiology; Human Molecular Genetics; Accounts of Chemical Research; PLoS ONE, Biochemistry; Frontiers in Non-Coding RNA...
Research Biography
The long-range goal of Dr. Yu's group is to elucidate the underlying biological principles and functional roles of posttranscriptional RNA modifications. Currently, They are particularly interested in 2'-O-methylation and pseudouridylation in three different types of RNA, including the spliceosomal snRNA involved in pre-mRNA splicing, the telomerase RNA required for telomere length maintenance, and the messenger RNA that encodes a chemical "blueprint" for the production of a protein.
Recent research of Dr. Yu's group has demonstrated that all these three types of RNA can be modified in vivo, either naturally or artificially through the RNA-guided RNA modification mechanisms. Importantly, our experimental data indicate that the posttranscriptional nucleotide modifications contribute significantly to RNA functions. They are currently carrying out three projects, aiming to address some of the fundamental questions regarding RNA modifications.
The long-range goal of Dr. Yu's group is to elucidate the underlying biological principles and functional roles of posttranscriptional RNA modifications. Currently, They are particularly interested in 2'-O-methylation and pseudouridylation in three different types of RNA, including the spliceosomal snRNA involved in pre-mRNA splicing, the telomerase RNA required for telomere length maintenance, and the messenger RNA that encodes a chemical "blueprint" for the production of a protein.
Recent research of Dr. Yu's group has demonstrated that all these three types of RNA can be modified in vivo, either naturally or artificially through the RNA-guided RNA modification mechanisms. Importantly, our experimental data indicate that the posttranscriptional nucleotide modifications contribute significantly to RNA functions. They are currently carrying out three projects, aiming to address some of the fundamental questions regarding RNA modifications.
