- 1.1.PRDM4 mediates YAP‐induced cell invasion by activating leukocyte‐specific integrin β2 expressionMay 14,20182018-05-14
- 2.2.Deubiquitylase USP9X suppresses tumorigenesis by stabilizing large tumor suppressor kinase 2 (LATS2) in the Hippo pathwayMay 14,20182018-05-14
- 3.3.Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancerMay 14,20182018-05-14
- 4.4.Small molecules promote CRISPR-Cpf1-mediated genome editing in human pluripotent stem cellsMay 14,20182018-05-14
- 5.5.Smad7 enables STAT3 activation and promotes pluripotency independent of TGF-β signalingMay 14,20182018-05-14
- 6.6.C-terminal domain small phosphatase-like 2 promotes epithelial-to-mesenchymal transition via Snail dephosphorylation and stabilizationMay 14,20182018-05-14
- 7.7.Sun S, Liu S, Zhang Z, Zeng W,Sun C,Tao T, Lin X,Feng X-H*.(2017) Phosphatase UBLCP1 controls proteasome assembly. Open Biology, 7(5):170042.September 11,20172017-09-11
- 8.10.Liu T*, Zhao M, Liu J, He Z, Zhang Y, You H, Huang J, Lin X, Feng XH*. (2017). Tumor suppressor bromodomain-containing protein 7 cooperates with smads to promote transforming growth factor-β responses. Oncogene, 36(3):362-372.August 22,20172017-08-22
- 9.11.Xu P, Lin X, Feng XH*.(2016). Posttranslational regulation of smads. Cold Spring Harbor Perspectives in Biology, 8(12), a022087.January 23,20172017-01-23
- 10.13.Chuang Sun, Gaohang Wang, Katharine H Wrighton,Han Lin,Zhou Songyang,Xin-Hua Feng*,Xia Lin*(2016). Regulation of p27kip1 phosphorylation and g1 cell cycle progression by protein phosphatase ppm1g. Am J Cancer Res, 6(10), 2207-2220.January 23,20172017-01-23
- 11.14.Feng XH*, Liang Y Y, Liang M, Zhai W, Lin X*. (2016). Direct interaction of c-myc with smad2 and smad3 to inhibit tgf-beta-mediated induction of the cdk inhibitor p15(ink4b). Molecular Cell, 63(6), 1089.January 23,20172017-01-23
- 12.15.Lin X*, Duan X, Liang YY, Su Y, Wrighton KH, Long J, Hu M, Davis CM, Wang J, Brunicardi FC, Shi Y, Chen YG, Meng A, Feng XH*.(2016)PPM1A Functions as a Smad Phosphatase to Terminate TGFβ Signaling.Cell,166(6):1597.January 23,20172017-01-23
- 13.19.Meng F,Zhou R,Wu S,Zhang Q,Jin Q,Zhou Y,Plouffe SW,Liu S, ong H,Xia Z,Zhao B,Ye S,Feng XH,Guan KL,Zou J,Xu P Mst1 shuts off cytosolic antiviral defense through IRF3 phosphorylation.2016 May 1;30(9):1086-100. doi: 10.1101/gad.277533.116.January 23,20172017-01-23
- 14.12.Liu S, Long J, Yuan B, Zheng M, Xiao M, Xu J, Lin X, Feng XH*. (2016). Sumo modification reverses inhibitory effects of smad nuclear interacting protein-1 in tgf-β responses. Journal of Biological Chemistry, 291(47), 24418-24430.October 12,20162016-10-12
- 15.21.Li Guan,Lei Zhang,Zhicheng Gong,Xiaonan Hou,Yuxiu Xu,Xinhua Feng,Hongyang Wang,Han You FoxO3 inactivation promotes human cholangiocarcinoma tumorigenesis and chemoresistance via Keap1-Nrf2 signaling.9 February 2016March 08,20162016-03-08
- 16.23.Mu Y, Lou J, Srivastava M, Zhao B, Feng XH, Liu T, Chen J*, Huang J*.SLFN11 inhibits checkpoint maintenance and homologous recombination repair.EMBO Rep. 2015 Dec 9. pii: e201540964.January 27,20162016-01-27
- 17.24.Gaohang Wang, Yi Yu, Chuang Sun, Ting Liu, Tingbo Liang, Lixing Zhan, Xia Lin and Xin-Hua Feng.STAT3 selectively interacts with Smad3 to antagonize TGF-β.Oncogene advance online publication 30 November 2015;doi: 10.1038/onc.2015.446December 03,20152015-12-03
- 18.28.Shen S,Guo X,Yan H,Lu Y,Ji X,Li L,Liang T,Zhou D,Feng XH,Zhao JC,Yu J,Gong XG,Zhang L,Zhao B.A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis.Cell Res.2015;25:997-1012September 09,20152015-09-09
- 19.30.Chen FF, Lin X, Xu PL, Zhang ZM, Chen YZ, Wang C, Han JH, Zhao B, Xiao M, Feng XH*. Nuclear export of Smads by RanBP3L regulates BMP signaling and mesenchymal stem cell differentiation. Molecular and Cellular Biology. 2015;35(10):1700-11.May 09,20152015-05-09
- 20.31.Chen W, Wu J, Li J, Zhang ZM, Liang Y, Chen F, Zhou Z, Su SS, Zheng X, Zhang Z, Zhong CQ, Wan H, Xiao M, Lin X, Feng XH, Han J. Ppm1b negatively regulates necroptosis through dephosphorylating Rip3. Nature Cell Biol.2015; 17(4):434-44.February 06,20152015-02-06
- 21.32.Strand DW, Liang YY, Yang F, Barron DA,Ressler SJ, Schauer IG,Feng XH and Rowley DR. TGF-β induction of FGF-2 expression in stromal cells requires integrated smad3 and MAPK pathways. Am J Clin. Exp Urol. 2014;2(3): 239-48.December 01,20142014-12-01
- 22.33.Lin YC,Lu LT,Chen HY,Duan X, Lin X, Feng XH, Tang MJ, Chen RH. SCP phosphatases suppress renal cell carcinoma by stabiling PML and inhibiting mTOR/HIF signaling. Cancer Res.2014;74(23): 6935-46.December 01,20142014-12-01
- 23.34.Wang A, Pan D, Lee YH, Martinez GJ, Feng XH, Dong C.Cutting edge: Smad2 and Smad4 Regulate TGF-β-Mediated Il9 Gene Expression via EZH2 Displacement. J Immunol.2013;191(10):4908-12.November 15,20142014-11-15
- 24.35.Chen J, Xia Y, Lin X, Feng XH, Wang Y.Smad3 signaling activates bone marrow-derived fibroblasts in renal fibrosis.Lab Invest.2014;94(5):545-56.November 01,20142014-11-01
- 25.36.Zhao YL, Xiao M, Sun B, Zhang Z, Shen T, Duan X, Yu P, Feng XH* and Lin X*.CTD Small Phosphatase Like 2 Modulates the Canonical BMP Signaling and Mesenchymal Differentiation via Smad Dephosphorylation.J Biol Chem.2014;289(38):26441-50.August 06,20142014-08-06
- 26.37.Shen T, Sun C, Zhang Z, Xu N, Duan X, Feng XH* and Lin X*. Specific control of BMP signaling and mesenchymal differentiation by cytoplasmic phosphatase PPM1H.Cell Res. 2014;24(6):727-41.April 15,20142014-04-15
- 27.38.Xue J, Lin X , Chiu WT, Chen YH, Yu G, Liu M, Feng XH, Sawaya R, Medema RH, Hung MC, Huang S. Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-β-dependent cancer metastasis.J Clin Invest.2014;124(2):564-79.February 03,20142014-02-03
- 28.39.Feng Y.Wu H. Xu Y. Zhang Z. Liu T. Lin X and Feng XH*. Zinc Finger Protein 451 is a novel Smad corepressor in Transforming Growth Factor-β signaling. J Biol Chem. 2014;289(4):2072-83.January 24,20142014-01-24
- 29.41.Zhou G, Wang H, Liu SH, Shahi, KW, Lin X, Feng XH, Qin J, Tan TH, Brunicardi FC.p38 MAP kinase interacts with and stablizws pancreatic and duodenal homeobox-1. Curr Mol Med.2013;13(3):377-86.May 01,20132013-05-01
- 30.44.Zhou G, Liu SH, Shahi KM, Wang H, Duan X, Lin X, Feng XH, Li M, Fisher WE, Demayo FJ, Dawson D, Brunicardi FC. Negative regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype. Mol Endocrinol.2012; 26(7):1225-34.June 05,20122012-06-05
- 31.45.Jia S, Dai F, Wu D, Lin X, Xing C, Xue Y, Wang Y, Xiao M, Wu W, Feng XH*and Meng AM*. Protein phosphatase 4 cooperates with Smads to promote BMP signaling in dorsoventral patterning of zebrafish embryos. Dev Cell. 2012; 22(5):1065-78.May 15,20122012-05-15
- 32.47.Dai F, Shen T, Li Z, Lin X, Feng XH*. PPM1A dephosphorylates RanBP3 to enable efficient nuclear export of Smad2 and Smad3. EMBO Rep. 2011;12(11):1175-81.September 30,20112011-09-30
- 33.48.Liu T and Feng XH*. Regulation of TGF-β signaling by protein phosphatases. Biochem J. 2010; 430(2):191-8.November 01,20102010-11-01
- 34.49.Martinez GJ, Zhang Z, Reynolds JM, Tanaka S, Chung Y, Liu T, Robertson E, Lin X, Feng XH* and Dong C. SMAD2 positively regulates the generation of Th17 cells. J Biol Chem. 2010; 285(38): 29039-43.July 28,20102010-07-28
- 35.51.Feng XH*. The changing faces of cancer cells. Nat Rev Mol Cell Biol. 2010; 11(7): 466.June 10,20102010-06-10
- 36.52.Dai F, Duan X, Liang YY, Lin X, Feng XH*. Coupling of dephosphorylation and nuclear export of Smads inTGF-β signaling. Methods Mol Biol. 2010; 647:125-37.May 10,20102010-05-10
- 37.53.Martinez GJ, Zhang Z, Chung Y, Reynolds JM, Lin X, Jetten AM, Feng X-H*, and Dong C*.Smad3 differentially regulates the induction of regulatory and inflammatory T cell differentiation. J Biol Chem.2009;284(51):35283-6.November 02,20092009-11-02
- 38.60.Wrighton KH, Lin X, Yu PB, and Feng XH*.TGF-β stimulates Smad1 phosphorylation independently of BMP receptors. J Biol Chem.2009; 284(15):9755-63.April 10,20092009-04-10
- 39.54.Dai F, Lin X, Chang C, and Feng XH*. Nuclear export of Smad2 and Smad3 by RanBP3 facilitate termination of TGF-β signaling. Dev Cell. 2009; 16(3):345-57.January 22,20092009-01-22
- 40.55.Li C, Liang YY, Feng XH, Tsai SY, Tsai MJ, and O’Malley BW.Essential phosphatases and a phospho-degron are critical for regulation of SRC-3/AIB1 coactivator function and turnover. Mol Cell.2008; 31(6): 835-49.December 08,20082008-12-08
- 41.57.Wrighton KH, Dai F, and Feng XH*. A new kid on the TGF-β block: TAZ controls Smad nucleo-cytoplasmic shuttling. Dev Cell. 2008; 15(1): 8-10.June 10,20082008-06-10
- 42.58.Wang D, Long J, Dai F, Liang M, Feng XH, Lin X.Bcl6 represses Smad signaling in TGF-β resistance. Cancer Res.2008; 68(3): 783-9.February 01,20082008-02-01
- 43.59.Wrighton KH, Lin X, and Feng XH*. Critical regulation of TGF-β signaling by HSP90. Proc Natl Acad Sci U S A. 2008; 105(27): 9244-9.January 07,20082008-01-07
- 44.62.Dai F, Chang C, Lin X, Dai P, Mei L, and Feng XH*. Erbin inhibits TGF-β signaling through a novel Smad-interacting domain. Mol Cell Biol. 2007; 27(17): 6183-94.June 25,20072007-06-25
- 45.63.Zhang S, Fei T, Zhang L, Zhang R, Chen F, Ning Y, Han Y, Feng XH, Meng M, Chen YG.Smad7 antagonizes TGF-β signaling in the nucleus by interfering with functional Smad-DNA complex formation. Mol Cell Biol.2007; 27(12): 4488-99.June 01,20072007-06-01
- 46.64.Wrighton K, Liang M, Bryan B, Luo K, Liu M, Feng XH, Lin X.TGF-β-independent regulation of myogenesis by SnoN SUMOylation. J Biol Chem.2007; 282(9): 6517-24.March 02,20072007-03-02
- 47.65.Ishinaga H, Jono H, Lim JH, Kweon SM, Xu H, Ha U, Xu H, Feng XH, Chen L, Li JD.TGF-β induces p65 acetylation to enhance bacteria-induced NF-kB activation.EMBO J.2007; 26(4): 1150-62.February 21,20072007-02-21
- 48.66.Wang J, Li A, Wang Z, Feng XH, Olson EN, Schwartz RJ.Myocardin sumoylation transactivates cardiogenic genes in pluripotent 10T1/2 fibroblasts. Mol Cell Biol.2007; 27(2):622-32.January 01,20072007-01-01
- 49.67.Wrighton, K, Willis D, Long J, Liu F, Lin X, Feng XH*.Small carboxy-terminal domain phosphatases dephosphorylate the regulatory linker regions of Smad2 and Smad3 to enhance TGF-β signaling. J Biol Chem.2006; 281(50): 38365–75.December 15,20062006-12-15
- 50.68.Duan X, LiangYY, Feng XH, Lin X.Protein phosphatase PPM1A dephosphorylates Smads in the BMP signaling pathway.J Biol Chem.2006; 281(48): 36526-32.December 01,20062006-12-01
- 51.69.Lin X, Duan X, Liang YY, Su Y, Wrighton KH, Long J, Hu M, Davis CM, Wang J, Brunicardi FC, Shi Y, Chen YG, Meng A, and Feng XH*. PPM1A functions a Smad phosphatase to terminate TGF-β signaling. Cell. 2006; 125(5): 915-28.June 02,20062006-06-02
- 52.70.Feng XH* and Derynck R*.Specificity and versatility of TGF-β signaling through Smads. Annu Rev Cell Dev Biol. 2005; 12: 659-93.July 01,20052005-07-01
- 53.71.Miura M, Chen XD, Gronthos S, Bi Y, Allen MR, Lakhani S, Flavell RA, Feng XH, Robey PG, Young M, Shi S.A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells.J Clin Invest.2004; 114(12): 1704-13.December 15,20042004-12-15
- 54.72.Liang M, Liang YY, Wrighton KH, Ungermannova D, Wang X, Brunicardi FC, Liu X, Feng XH*, and Lin X*. Ubiquitination and proteolysis of cancer-derived Smad4 mutants by SCFSkp2. Mol Cell Biol. 2004; 24(17): 7524-37.November 24,20042004-11-24
- 55.73.Wang J, Feng XH, Schwartz R.SUMO-1 modification activated GATA4 dependent cardiogenic gene activity. J Biol Chem.2004; 279(47): 49091-8.November 09,20042004-11-09
- 56.74.Liang M, Melchior F, Feng XH, Lin X.Regulation of Smad4 sumoylation and TGF-β signaling by PIAS1. J Biol Chem.2004; 279(22): 22857–65.May 28,20042004-05-28
- 57.75.Li GQ, Wang D, Feng XH, Wang XJ.Latent TGF-β 1 overexpression in keratinocytes results in a severe psoriasis-like skin disorder.EMBO J.2004; 23(8): 1770-81.April 01,20042004-04-01
- 58.76.Brown CO 3rd, Chi X, Garcia-Gras E, Shirai M, Feng XH, Schwartz R.The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer. J Biol Chem.2004; 279(11): 10659-69.March 12,20042004-03-12
- 59.77.Lin X, Liang YY, Sun B, Liang M, Brunicardi FC, Feng XH*. Smad6 recruits transcription corepressor CtBP to repress BMP-induced transcription. Mol Cell Biol.2003; 23(24): 9081-93.December 01,20032003-12-01
- 60.78.Lin X, Liang M, Liang YY, Brunicardi FC, Feng XH*. SUMO/Ubc9 promotes nuclear accumulation and metabolic stability of tumor suppressor Smad4. J Biol Chem.2003; 278(33): 31043-8.August 15,20032003-08-15
- 61.80.Lin X, Liang M, Liang YY, Brunicardi FC, Melchior F, and Feng XH*. Activation of TGF-β signaling by SUMO modification of tumor suppressor Smad4/DPC4. J Biol Chem, 2003; 278:18714-18719.May 23,20032003-05-23
- 62.81.Lin X, Liang M, Liang YY, Brunicardi FC, Melchior F, and Feng XH*. Activation of TGF-β signaling by SUMO modification of tumor suppressor Smad4/DPC4. J Biol Chem. 2003; 278(21):18714-9.May 23,20032003-05-23
- 63.82.Lin X, Sun B, Liang M, Liang YY, Gast A, Hildebrand J, Brunicardi FC, Melchior F, and Feng XH*. Opposed regulation of corepressor CtBP by SUMOylation and PDZ binding. Mol Cell. 2003; 11(5): 1389-96.May 05,20032003-05-05
- 64.83.Feng XH*,Liang YY, Liang M, Zhai W, and Lin X*. Direct interaction of oncogenic c-Myc with tumor suppressors Smad2 and Smad3 to inhibit TGF-β-mediated induction of the CDK inhibitor p15INK4B. Mol Cell. 2002; 9(1): 133-43.January 01,20022002-01-01
- 65.84.Lin X, Liang M, Feng XH*.Smurf2 as a ubiquitin E3 ligase for proteasome-dependent degradation of Smad2 in TGF-β signaling.J Biol Chem.2000; 275(47): 36818-22.November 24,20002000-11-24
- 66.85.Feng XH*, Lin X, Derynck R. Smad2, 3, 4 and Sp1 cooperate to induce transcription of cyclin-dependent kinase inhibitor p15Ink4B in response to TGF-β. EMBO J.2000; 19(19): 5178-93.February 10,20002000-02-10
- 67.86.Dong C, Li Z, Alvarez R Jr, Feng XH, Goldschmidt-Clermont PJ. Microtubule binding to Smads may regulate TGF-β activity. Mol Cell.2000; 5(1): 27-34.January 01,20002000-01-01
