We utilize multidisplinary approaches to study molecular mechanisms of bacterial-host interactions. Our major studies are focusing on the following sections:

(1) Pathogenic bacteria-host interactions.

Gram-negative bacterial pathogens such as Shigella flexneri, Enteropathogenic E.coli, and Legionella pneumophila inject many virulent proteins (also termed as effector proteins) into host cells through specialized secretion systems. The injected effectors target the host key signal molecules to modulate host cellular processes for bacterial infection and multiplication, which plays a central role in bacterial pathogenesis. We are focusing on identification of the novel biochemical activities and functions of these effector proteins.

(2) Commensal bacteria-host interactions

Commensal bacteria in the intestine play important role in human health. The unique enzymes in commensal bacteria synthesize and produce necessary metabolites for human cells, which can activate host immune signaling. Commensal bacteria also compete with bacterial pathogens and inhibit the growth of pathogenic bacteria. We will combine approaches of micriobiology, bioinformatics, cell biology and germ-free mouse model to study how commensal bacteria interact with host cells.