Representative publications

(# Co-first author; * Corresponding author)

After joining Zhejiang University:

1. Liang C#, Zhang Z#, Chen Q, Yan H, Zhang M, Zhou L, Xu J, Lu W, Wang F*. Centromere-localized Aurora B kinase is required for the fidelity of chromosome segregation. Journal of Cell Biology, 2020 Feb 3;219(2). pii: e201907092. doi: 10.1083/jcb.201907092.

2. Zhang M, Liang C, Chen Q, Yan H, Xu J, Zhao H, Yuan X, Liu J, Lin S, Lu W, Wang F*. Histone H2A phosphorylation recruits topoisomerase IIα to centromeres to safeguard genomic stability. EMBO Journal, 2019: e101863. doi: 10.15252/embj.2019101863. [Epub ahead of print].

3. Li M, Xu X, Zhang J, Liu M, Wang W, Gao Y, Sun Q, Zhang J, Lu Y, Wang F, Liu W, Zhou T*, Yang Y*. NudC-like protein 2 restrains centriole amplification by stabilizing HERC2. Cell Death & Disease, 2019, 10 (9): 628.doi: 10.1038/s41419-019-1843-3.

4. Yi Q#, Chen Q#, Yan H, Zhang M, Liang C, Xiang X, Pan X, Wang F*. Aurora B kinase activity-dependent and -independent functions of the chromosomal passenger complex in regulating sister chromatid cohesion. Journal of Biological Chemistry, 2019, 294 (6): 294, 2021-2035.

5. Liang C#, Zhang Z#, Chen Q, Yan H, Zhang M, Xiang X, Yi Q, Pan X, Cheng H, Wang F*. A positive feedback mechanism ensures proper assembly of the functional inner centromere during mitosis in human cells. Journal of Biological Chemistry, 2019, 294 (5): 1437-1450.

6. Yang Y#*, Wang W#, Li M#, Gao Y, Zhang W, Huang Y, Zhuo W, Yan X, Liu W, Wang F, Chen D*, Zhou T*. NudCL2 is an Hsp90 cochaperone to regulate sister chromatid cohesion by stabilizing cohesin subunits. Cellular and Molecular Life Sciences, 2019, 76 (2): 381-395.

7. Yan H#*, Xiang X#, Chen Q, Pan X, Cheng H, Wang F*. HP1 cooperates with CAF-1 to compact heterochromatic transgene repeats in mammalian cells. Scientific Reports, 2018, 8:14141, doi:10.1038/s41598-018-32381-7.

8. Qi F, Chen Q, Chen H, Yan H, Chen B, Xiang X, Liang C, Yi Q, Zhang M, Cheng H, Zhang Z, Huang J, Wang F*. WAC promotes Polo-like kinase 1 activation for timely mitotic entry. Cell Reports, 2018, 24, 546-556.

9. Yi Q#, Chen Q#, Liang C, Yan H, Zhang Z, Xiang X, Zhang M, Qi F, Zhou L, Wang F*. HP1 links centromeric heterochromatin to centromere cohesion in mammals. EMBO Reports, 2018, 19: e45484.
     - Commented by Javerzat J, EMBO Reports, 2018, 19(4): e45980.

10. Liang C#, Chen Q#, Yi Q, Zhang M, Yan H, Zhang B, Zhou L, Zhang Z, Qi F, Ye S, Wang F*. A kinase-dependent role for Haspin in antagonizing Wapl and protecting mitotic centromere cohesion. EMBO Reports, 2018, 19 (1): 43-56.

11. Zhou L#, Liang C#, Chen Q, Zhang Z, Zhang B, Yan H, Qi F, Zhang M, Yi Q, Guan Y, Xiang X, Zhang X, Ye S, Wang F*. The N-terminal non-kinase domain-mediated binding of Haspin to Pds5B protects centromeric cohesion in mitosis. Current Biology, 2017, 27 (7): 992-1004.

12. Yu F, Jiang Y, Lu L, Cao M, Qiao Y, Liu X, Liu D, Van Dyke T, Wang F, Yao X, Guo J*, Yang Z*. Aurora-A promotes the establishment of spindle assembly checkpoint by priming the Haspin-Aurora-B feedback loop in late G2 phase. Cell Discovery, 2017, 3:16049, eCollection.

13. Zhou L#, Tian X#, Zhu C, Wang F*, Higgins JM*. Polo-like kinase-1 triggers histone phosphorylation by Haspin in mitosis. EMBO Reports, 2014, 15 (3): 273-281.
     - Commented by Moutinho-Santos T & Maiato H. EMBO Reports. 2014, 15(3): 203-4.

14. Wang F*, Higgins JM*. Histone modifications and mitosis: countermarks, landmarks and bookmarks. Trends in Cell Biology, 2013, 23 (4): 175-184.

Before joining Zhejiang University:

15. Wang F, Ulyanova N, Daum JR, Patnaik D, Kateneva AV, Gorbsky GJ, Higgins JM*. Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation. Journal of Cell Biology, 2012, 199 (2): 251-268.

16. Niedzialkowska E, Wang F, Porebski PJ, Manukyan A, Minor W, Higgins JM*, Stukenberg T*. Molecular basis for phosphospecific recognition of Histone H3 tails by Survivin paralogs at inner centromeres. Molecular Biology of the Cell, 2012, 23 (8): 1457-1466.

17. Wang F, Ulyanova N, Waal MS, Patnaik D, Lens SM, Higgins JM*. A positive feedback loop involving Haspin and Aurora B promotes CPC accumulation at centromeres in mitosis. Current Biology, 2011, 21 (12): 1061-1069.

18. Varier R, Outchkourov N, Graaf P, Schaik F, Ensing H, Wang F, Higgins JM, Kops G, Timmers M*. A phospho/methyl switch at histone H3 regulates TFIID association with mitotic chromosomes. EMBO Journal, 2010, 29 (23): 3967-3978.

19. Wang F, Dai J, Daum JR, Niedzialkowska E, Banerjee B, Stukenberg T, Gorbsky GJ, Higgins JM*. Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis. Science, 2010, 330 (6001): 231-235.
     - Commented by Musacchio A, Science, 2010, 330(6001): 183-4.

20. Eswaran J*#, Patnaik D#, Filippakopoulos P#, Wang F, Stein RL, Murray JW, Higgins JM*, Knapp S*. Structure and functional characterization of the atypical human kinase haspin. PNAS, 2009, 106 (48): 20198-201203.

21. Wang F, Koyama N, Nishida H, Haraguchi T, Reith W, Tsukamoto T*. The assembly and maintenance of heterochromatin initiated by transgene repeats are independent of the RNA interference pathway in mammalian cells. Molecular and Cellular Biology, 2006, 26 (11): 4028-4040.