H index=52, SCI citations>14500 (Web of Science, 2023) ; citation in latest 5 years>8500；   *Corresponding author; #Co-first authors;


·         Li H, Liu C, Li R, Zhou L, Ran Y, Yang Q, Huang H, Lu H, Song H, Yang B, Ru H, Lin S, Zhang L*. AARS1/2 senses L-lactate to regulate cGAS as global lysine lactyltransferase. Nature. 2024
·      Zou J, Qin Z, Li R, Yan X, Huang H*, Yang B*, Zhou F*, Zhang L*. iProPhos: a web-based interactive plastform for integrated proteome and phosphoproteome analysis. Molecular & Cellular Proteomics. 2024
·       Ren J, Wang S, Zong Z, Pan T, Liu S, Mao W, Huang H, Yan X, Yang B, He X, Zhou F*, Zhang L*. TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence. Nature Commaunications. 2024
·         Yuan X, Yan L, Chen Q, Zhu S, Zhou X, Zeng L, Liu M, He X, Huang J, Lu W, Zhang L*, Yan H*, Wang F*. Molecular mechanism and functional significance of Wapl interaction with the Cohesin complex. Proceedings of the National Academy of Sciences (PNAS). 2024
·      Wan S, Zhou X, Xie F*, Zhou F*, Zhang L*. Ketogenic diet and cancer: multidimensional exploration and research. Science China Life Sciences. 2024
·      Ren J, Liu S, Zhang L*. Inhibitor of differentiation 3 (ID3) confers the robust anti-tumor activity of Kupffer cells. MedComm. 2024
·      Bai L, Zhou F*, Zhang L*. Booster vaccination: host preparation against omicron challenge by innate immunity training. MedComm. 2024
·      Guo H, Zhou F*, Zhang L*. Nε-Acetyl-Nε-methyllysine: a new post-translational modification to mark chromatin. MedComm-Future Medicine. 2024
·      Bai L, Zhou F*, Zhang L*. Serotonin signaling: a new player and therapeutic target beyond long-haul coronavirus disease. MedComm. 2024
·      Wei X, Zhou F*, Zhang L*. PARP1-DNA co-condensation: the driver of broken DNA repair. Signal Transduction and Targeted Therapy. 2024
·      Zou J, Qin Z, Zhang L*. High-resolution spatiotemporal mapping: a comprehensive view of eukaryotic cell cycle proteome dynamics. Signal Transduction and Targeted Therapy. 2024
·      Gu Y, Zhou X, Zhang L*. Advances in the elucidation of CircRNA translocation. MedComm-Future Medicine. 2024
·      Bai L, Xu J, Zeng L*, Zhang L*, Zhou F*. A review of HSV pathogenesis, vaccine development, and advanced applications. Molecular Biomedicine. 2024
·     Zhang M, Li J, Liu S, Zhou F*, Zhang L*. UCHL5 is a putative prognostic marker in renal cell carcinoma: a study of UCHL family. Molecular Biomedicine. 2024
·      Zhou X, Wu Y, Zhu Z, Lu C, Zhang C, Zeng L, Xie F, Zhang L*, Zhou F*. Mucosal immune response in biology, disease prevention and treatment. Signal Transduction and Targeted Therapy. 2024
·      Shang Y, Shu X, Lu Y, Zhu W, Li R, Fu H, Li C, Sun W, Li Z, Zhang Y, Cao X, Ye X, Emmanuel A, Zhao B, Zhang L, Wu H, Feng XH, Yang B, Lu H. A chaperon-like function of FUS ensures TAZ condensate dynamics and transcriptional activation. Nature Cell Biology. 2024
·     Ding W, Liu C, Chen Y, Gu J, Fang C, Hu L, Zhang L, Yuan Y, Feng XH, Lin S. Computational design and genetic incorporation of lipidation mimics in living cells. Nature Chemical Biology. 2024
·      Yan L, Yuan X, Liu M, Chen Q, Zhang M, Xu J, Zeng LH, Zhang L, Huang J, Lu W, He X, Yan H, Wang F. A non-canonical role of the inner kinetochore in regulating siter-chromatid cohesion at centromeres. EMBO Journal. 2024
·     Liu D, Ding W, Cheng J, Wei Q, Lin Y, Zhu T, Tian J, Sun K, Zhang L, Lu P, Yang F, Liu C, Tang S, Yang B. Characterize direct protein interactions with enrichable, cleavable and latent bioreactive unnatural amino acids. Nature Communications. 2024
·      Li C, Xu X, Geng Z, Zheng L, Song Q, Shen X, Wu J, Zhao J, Li H, He M, Tai X, Zhang L, Mao J, Dong Y, Ren A. Structure-based characterization and compound identification of the wild-type THF class-II riboswitch. Nucleic Acids Research. 2024
·      Tan L, Yan M, Su Z, Wang H, Li H, Zhao X, Liu S, Zhong L, Sun Q, Lu D. R-spondin-1 induces Axin degradation via the LRP6-CK1e axis. Cell Communication and Signaling. 2024
·      Dong X, Lin Y, Li K, Liang G, Huang X, Pan J, Wang L, Zhang D, Liu T, Wang T, Yan X, Zhang L, Li X, Qu X, Jia D, Li Y, Zhang H. Consensus statement on extracellular vesicles in liquid biopsy for advancing laboratory medicine. Clinical Chemistry and Laboratory Medicine. 2024
·      Dai T, Zhang L, Ran Y, Zhang M, Yang B, Lu H, Liu J, Lin S*, Zhang L*, Zhou F*. DeSUMOylation by SENP1 inhibits MAVS aggregation and antagonizes IRF3 activation. Nature Structure & Molecular Biology. 2023
·      Pan C, Zhou F*, Zhang L*. The loss of epigenetic information: not only consequences but a cause of mammalian aging. Signal Transduction and Targeted Therapy. 2023
·      Liu S, Ren J, Zhang L*. RHOJ: a key regulator of EMT-associated resistance to chemotherapy. Signal Transduction and Targeted Therapy. 2023
·      Li R, Zou J, Pei D, Pan T, Yang B, Liu X, Chen Y*, Zhou F*, Zhang L*. Deciphering dynamic changes of the aging transcriptome with COVID-19 progression and convalescence in the human blood. Signal Transduction and Targeted Therapy. 2023
·      Ren J, Wang S, Zong Z, Pan T, Liu S, Mao W, Huang H, Yan X, Yang B, He X, Zhou F*, Zhong L*. TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence. Nature Communications. 2023
·      Z Zong, Zhou F*, Zhang L*. The fungal mycobiome: a new hallmark of cancer revealed by pan-cancer analyses. Signal Transduction and Targeted Therapy. 2023
·      Su P, Zhou F*, Zhang L*. Motile cilia and microvillar: accomplices of SARS-CoV-2 in penetrating mucus barrier and infecting airway epithelium. Signal Transduction and Targeted Therapy. 2023
·       Gao Z, Wang B, Zhang L*. Activated STING: an icon channel to trigger non-interferon-related functions. Signal Transduction and Targeted Therapy. 2023
·      Yang Q, Wang B, Zheng Q, Li H, Meng X*, Zhou F*, Zhang L*. A review of gut microbiota-derived metabolites in tumor progression and cancer therapy. Advanced Science. 2023

·      Su P, Wu Y, Xie F, Zeng Q, Chen L, Liu Z, Meng X*, Zhou F*, Zhang L*. A review of extracellular vesicles in COVID-19 diagnosis, treatment and prevention. Advanced Science. 2023
·      Ren J, Yu P, Liu S, Li R, Niu X, Chen Y, Zhang Z*, Zhou F*, Zhang L*. Deubiquitylating enzymes in cancer and immunity. Advanced Science. 2023
·       Lan T, Zhou F*, Zhang L*. WNK1, a molecular crowding sensor, links phase separation to cellular physiological stress.  MedComm. 2023
·       Kuang Y, Sun W, Zhang L*. The presence of Y chromosome leads to the difference of cancer in patients with different sexes.  MedComm. 2023
·      Yang Q, Zhang L*, Chen J*. Lactate, a critical regulator of cell proliferation via anaphase promoting complex remodeling. MedComm-Oncology. 2023
·      Tu Y, Zhou F*, Zhang L*. SIK3-HDAC4 signaling pathway: the swith for transition between sleep and wakefulness.  Molecular Biomedicine. 2023
·      Niu X, Zhou F*, Zhang L*. Microglia regulate the health of central nervous system through myelin. Molecular Biomedicine. 2023
·       Pan C, Xiao Z, Wu C, Zhang L*, Jia J*, Zhen M*. A new method to synthesize multiple gRNA libraries and functional mapping of mammalian H3K4me3 regions. Nucleic Acid Research. 2023
·      Guan J, Zhang L*, Zhou F*. TBK1: a new target for overcoming cancer immunotherapy resistance. Science China Life Sciences. 2023
·       Niu X, Zhang L, Wu Y, Zong Z, Wang B, Liu J*, Zhang L*, Zhou F*. Biomolecular condensates: formation mechanisms, biological functions and therapeutic targets. MedComm. 2023
·       Wu T, Li S, Ran Y, Lin Y, Liu L, Zhang X, Zhou L, Zhang L, Wu D, Yang B, Tang S. Mapping protein direct interactome of oxidoreductases with small molecular chemical cross-linkers in live cells. Redox Biology. 2023
·      Shu X, Liao QQ, Li ST, Liu L, Zhang X, Zhou L, Zhang L, Coin I, Wang L, Wu H, Yang B. Detecting active deconjugating enzymes with genetically encoded activity-based ubiquitin and ubiquitin-like protein probes. Analytical Chemistry. 2023   
·      Shu X, Liao QQ, Li ST, Liu L, Zhang X, Zhou L, Zhang L, Coin I, Wang L, Wu H, Yang B. Detecting active deconjugating enzymes with genetically encoded activity-based ubiquitin and ubiquitin-like protein probes. Analytical Chemistry. 2023    
·       Qin Z, Fang X, et al., Zhou F*, Zhang L*. Deacetylation by SIRT1 enables liquid-liquid phase separation of IRF3/IRF7 in innate antiviral immunity. Nature Immunology. 2022
·       Zhou F*, Zhang L*. IRF3 and IRF7 require SIRT1 for LLPS and transactivation of IFN-I. Nature Immunology. 2022
·       Xie F, Zhou X, Li H, Su P, Liu S, Li R, Zou J, Wei X, Pan C, Zhang Z, Zheng M, Liu Z, Meng X, Ovaa H, Ten Dijke P*, Zhou F*, Zhang L*. USP8 promotes cancer progression and extracellular-vesicle mediated CD8+ T cell exhaustion by deubiquitinating TGF-β receptor TβRII. EMBO Journal. 2022
·      Xie F, Zhou X, Su P, Li H, Tu Y, Du J, Pan C, Wei X, Zheng M, Jin K, Miao L, Wang C, Meng X, Van Dam H, Ten dijke P, Zhang L*, Zhou F*. Breast Cancer Cell-derived Extracellular Vesicles Promote CD8+ T cell Exhaustion via TGF-β type II receptor Signalling. Nature Communications. 2022
·      Wang S, Chu F, Xia R, Guan J, Zhou L, Fang X, Dai T, Xie F, Zhang L and Zhou F*. LPA Maintains Innate Antiviral Immunity in a pro-active state via STK38L-Mediated IRF3 Ser303 Phosphorylation. Cell Reports. 2022
·       Fang X, Zhang L*. ZBP1 contributes to interferonopathies caused by impaired ADAR1 function. Molecular Biomedicine. 2022
·       Guan J，Zhang L*, Zhou F*. PI3K-PANK4: a new target for de novo synthesis of coenzyme A. Molecular Biomedicine. 2022
·       Wang B, Zhang L, Zhou F*. Zhang L*. Potential mechanisms by which impaired ketogenesis links metabolism to T-cell dysfunction in patients with severe COVID-19. Medcomm. 2022         
·       Wei X, Xie F, Zhou X, Yan H, Liu T, Huang J*, Wang F*, Zhou F*, Zhang L*. Developments in the understanding of pyroptosis and its potential role in the treatment of inflammation and cancer. Cellular & Molecular Immunology. 2022
·       Su P, Zhang L, Zhou F*, Zhang L*. Circular RNA vaccine, a novel mRNA vaccine design strategy for SARS-COV-2 and variants. MedComm. 2022
·       Li J, Zhang M, Ma W, Yang B, Lu H, Zhou F*, Zhang L*. Post-translational modifications in liquid-liquid phase separation：A comprehensive review. Molecular Biomedicine. 2022
·      Zhao L, Zhou X, Xie F, Zhang L, Yan H, Huang J, Zhang C*, Zhou F*, Chen J*,  Zhang L*. Ferroptosis in cancer and cancer immunotherapy. Cancer Communications. 2022
·      Wang Y, Zhou F*, Zhang L*. Cuprotosis: A new form of programmed cell death. Cellular & Molecular Immunology. 2022
·      Li H, Zhou F*, Zhang L*. STING, a critical contributor to SARS-CoV-2 immunopathology.  Signal Transduction and Targeted Therapy. 2022
·      Qin Z, Zhou F*, Zhang L*. Novel pyroptosis-independent functions of gasdermins.  Signal Transduction and Targeted Therapy. 2022
·      Wang B, Zhang L, Wang Y, Dai T, Qin Z, Zhou F, Zhang L*. Alteration in microbiota of Patients with COVID-19: Potential mechanisms and therapeutic interventions.  Signal Transduction and Targeted Therapy. 2022
·       Ren J，Zhang Z, Zong Z, Zhang L*, Zhou F*. Emerging implications of phase separation in cancer. Advanced Science. 2022
·       Pei D, Zhang L*, Zhang Z*. Tumor–neuron interactions: a novel concept contributor to glioblastoma invasion.  MedComm-Oncology. 2022
·       Wang Y，Fang X, Wang S, Wang B, Chu F, Zhang L*, Zhou F*. The role of O-GlcNAcylation in innate immunity and inflammation. Journal of Molecular Cell Biology. 2022 
·       Xie Y，Xie F, Zhou X，Zhang L, Yang B, Huang J, Wang F, Yan H, Zeng L*, Zhang L*, Zhou F*. Microbiota in tumors: from understanding to application. Advanced Science. 2022
·       Tu Y, Fang P, Zhang L*, Sun K*. Analysis of the effect of Snai family in breast cancer and immune cell. Front. Cell Dev. Biol. 2022
·      Fan Y, Xiang Li, Zhang L, Wan S*, Zhang L*, Zhou F*. SARS-CoV-2 Omicron variant: rencent progress and future perspectives. Signal Transduction and Targeted Therapy. 2022
·      Fan Y, Li X, Zhang L, Zhang L*, Zhou F*. SUMOylation in viral replication and  antiviral defense.  Advanced Science. 2022
·      Editorial: TGF-β and BMP signaling in cancer. Yan X, Zhang L, Miyazawa K, Ten Dijke P.  Front. Cell Dev. Biol. 2022
·       Zheng L, Liu J, Niu L, Mohammad K, Yang A, Arttu J, Dai Q, Timothy R, Dinshaw J, Zhang L, Supriya G, Yang Y, Ren A, Eric C. Distinct structural bases for sequence-specific DNA binding by mammalian BEN domain proteins. Genes & development. 2022

·      Yao T, Wang S, Zhang L, Johnson L, Zhou F*. Opsonizing antibodies mediated SARS-CoV-2 entry into monocytes leads to inflammation. MedComm-Future Medicine. 2022
·     Huang Y, Liu S, Shan M et al., Zhang L, Li D, Ten Dijke P. RNF12 is regulated by AKT phosphorylation and promotes TGF-β driven breast cancer metastasis. Cell Death Disease. 2022
·      Lyengar PV, Marvin DL, Lama D, Tan TZ, Suriyamurthy S, Xie F, van Dinther M, Mei H, Verma CS, Zhang L, Ritsma L, Ten Dijke P. TRAF4 inhibits bladder cancer progression by promoting BMP/SMAD signaling. Molecular Cancer Research. 2022

·     Xie F, Su P, Pan T, Zhou X, Li H, Huang H, Wang A, Wang F, Huang J, Yan H, Zeng LH, Zhang L*, Zhou F*. Engineering extracellular vesicles enriched with palmitoylated ACE2 as COVID-19 therapy. Advanced Materials. 2021
·     Li H, Zhou F*, Zhang L*. ADP-riboxanation-A new pyroptosis evasion strategy. Journal of Molecular Cell Biology. 2021
·      Dong Y, Dai T, Wang B, Zhang L, Zeng L, Huang J, Yan H, Zhang L*, Zhou F*. The way of SARS-CoV-2 vaccine development: sucess and challenges. Signal Transduction and Targeted Therapy. 2021

·     Fan Y, Zhang L*, Zhou F*. cGAS-like receptors: new RNA sensors in Drosophila. Signal Transduction and Targeted Therapy. 2021
·      Jin K, Zhou F, Zhang L*. Cancer Environment Immunotherapy: targeting TGF-β finds its way towards tissue healing and vasculature remodeling. Signal Transduction and Targeted Therapy. 2021 
·      Xie Y, Xie F, Zhang L, Zhou X, Huang J, Wang F, Jin J, Zhang L*, Zeng L*, Zhou F*. Targeted anti-tumor immunotherapy using tumor infiltrating cells. Advanced Science. 2021 
·      Cao J, Zhang M, Wang B, Zhang L*, Zhou F*, Fang M*. Chemoresistance and metastasis in breast cancer molecular mechanisms and novel clinical strategies. Frontiers in Oncology. 2021  
·   Wang S, Dai T, Qin Z, Pan T, Chu F, Lou L, Zhang L, Yang B, Huang H, Lu H, Zhou F. Targeting liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity via elevating MAVS activity. Nature Cell Biology. 2021
·       Wang B, Zhang L, Dai T, Qin Z, Lu H, Zhang L*, Zhou F*. Liquid-liquid phase separation in human health and diseases. Signal Transduction and Targeted Therapy. 2021 
·       Zong Z, Wei Y, Ren J, Zhang L, Zhou F. The intersection of COVID19 and cancer: signaling pathways and treatment implications. Molecular Cancer. 2021
·      Zheng Q, Zhang M, Zhou F, Zhang L, Meng X. The Breast Cancer Stem Cells Traits and Drug Resistance. Frontiers in Pharmacology. 2021
·      Wang B, Dai T, Ren J, Zhang L, Zhou F. Protein N-myristoylation: functions and mechanisms in control of innate immunity. Cellular & Molecular Immunology. 2021
·      Liu J, Yuan B, Cao J, Luo H, Gu S, Zhang M, Ding R, Zhang L, Zhou F, Hung MC, Xu P, Lin X, Jin J, Feng XH. AMBRA1 promotes TGF-β signaling via non-proteolytic polyubiquitylation of SMAD4. Cancer Research. 2021
·      Gao C, Deng J, Zhang H, Li X, Gu S, Zheng M, Tang M, Zhu Y, Jin J, Zhang L, Huang J, Zou J, Xia Z, Xu P, Shen L, Zhao B, Feng XH. HSPA13 facilitates NF-kB-mediated transcription and attenuates cell death responses in TNFa signaling. Science Adavances. 2021
·      Lin T, Wang S, et al., Zhang L, et al., Ding H, Weng HL. Follistatin-controlled activin-HNF4a-coagulation factor axis in liver progenitor cells determines outcome of acute liver failure. Hepatology. 2021
·      Chen Q, Zhang M, Pan X, Yuan X, Zhou L, Yan L, Zeng L, Xu J, Yang B, Zhang L, Huang J, Lu W, Fukagawa T, Wang F, Yan H. Bub1 and CENP-U redundantly recruit Plk1 to stabilize kinetochore-microtubule attachments and ensure acurate chromosome segregation. Cell Reports. 2021

·      Zhu Y, Yu J, Gu J, Xue C, Zhang L, Chen J, Shen L. Relaxed 3D genome conformation facilitates the pluripotent to totipotent-like transition in embryonic stem cells. Nucleic Acids Research. 2021
·  Liu S, Gonzalez-Prieto R, Zhang M, Geurink PP, Kooij R, Lyengar PV, van Dinther M, Bos E, Zhang X, Le Devedec SE, van de Water B, Koning RI, Zhu HJ, Mesker WE, Vertegaal ACO, Ovaa H, Zhang L,  Martens JWM, Ten Dijke P. Deubiquitinase activity profiling identifies UCHL1 as a candidate oncoprotein that promotes TGF-β-induced breast cancer metastasis. Clinical Cancer Research. 2020
·      Zhang Z, Fang X, Wu X, Chu F, Ling L, Li J, Wang S, Zang J, Zhang B, Ye S, Zhang L, Yang B, Lin S, Huang H, Wang A, Zhou F.  Acetylation-dependent deubiquitinase OTUD3 controls MAVS activation in innate antiviral immunity. Molecular Cell. 2020

·     Li T, Wu B, Yang T, Zhang L, Jin K. The outstanding antitumor capacity of CD4+ T helper lymphocytes. BBA-Reviews on Cancer. 2020
·      Cao J, Zhang M, Xie F, Lou J, Zhou X, Zhang L, Fang M, Zhou F. Exosomes in Head and Neck Cancer: Roles, Mechanisms and Applications. Cancer Letters. 2020
·      Cao J, Zhang M, Zhang L, Lou J, Zhou F, Fang M. Non-coding RNA in thyroid cancer-Functions and mechanisms. Cancer Letters. 2020
·     Zong Z, Zhang Z, Wu L, Zhang L, Zhou F. The functional deubiquitinating enzymes in control of innate antiviral immunity. Advanced Science. 2020
·     Dong Y, Dai T, Wei Y, Zhang L, Zheng M, Zhou F. A systematic review of SARS-CoV-2 vaccine candidates. Signal Transduction and Targeted Therapy. 2020
·       Dong Y, Dai T, Zhang L, Zhou F. Coronavirus in continuous flux: from SARS-CoV to SARS-CoV-2.  Advanced Science. 2020
·      Jin K, Zhang L, Zhou F. An Effective Platform for Cancer Immunotherapy: Pooled Knockin Targeting for Genome Engineering Immunotherapies. Signal Transduction and Targeted Therapy. 2020
·      Cheng Z, Dai T, He X, Zhang Z, Xie F, Wang S, Zhang L, Zhou F. The interaction between cGAS-STING pathway and pathogens. Signal Transduction and Targeted Therapy. 2020
·      Liu L, Wu Y, Zhang C, Zhou C, Li Y, Zeng Y, Zhang C, Li R, Luo D, Wang L, Zhang L, Tu S, Deng H, Luo S, Chen YG, Xiong X, Yan X. Cancer-associated adipocytes-derived G-CSF promotes breast cancer malignancy via Stat3 signaling.  J Mol Cell Biol. 2020
·      Zhou X, Xie F, Wang L, Zhang L, Zhang S, Fang M, Zhou F. The function and clinical application of extracellular vesicles in innate immune regulation. Cellular & Molecular Immunology. 2020  
·      Xie F, Zhou X, Fang M, Li H, Su P, Tu Y, Zhang L, Zhou F. Extracellular Vesicles in Cancer Immune Microenvironment and Cancer Immunotherapy.  Advanced Science. 2019
·      Fan KQ, Li YY, Wang HL, Mao XT, Guo JX, Wang F, Huang LJ, Li YN, Ma XY, Gao ZJ, Chen W, Qian DD, Xue WJ, Cao Q, Zhang L, Shen L, Zhang L, Tong C, Zhong JY, Lu W, Lu L, Ren KM, Zhong G, Wang Y, Tang M, Feng XH, Chai RJ, Jin J. Stress-Induced Metabolic Disorder in Peripheral CD4+ T cells leads to Anxiety-like Behavior. Cell. 2019 
·      Li Y, Cui C, Xie F, Kiełbasa S, Mei H, van Dinther M, van Dam H, Bauer A, Zhang L, Ten Dijke P. VprBP mitigates TGF-β and Activin signaling by promoting Smurf1-mediated type I receptor degradation. J Mol Cell Biol. 2019
·      Zhang Z, Du J, Wang S, Shao L, Jin K, Li F, Wei B, Ding W, Fu P, van Dam H, Wang A, Jin J, Ding C, Yang B, Zheng M, Feng XH, Guan KL, Zhang L*. OTUB2 promotes cancer metastasis via Hippo independent activation of YAP and TAZ. Molecular Cell. 2019
·     Dai T, Wu L, Wang S, Wang J, Xie F, Zhang Z, Fang X, Li J, Fang P, Li F, Jin K, Dai J, Yang B, Zhou F, van Dam H, Cai D, Huang H,  Zhang L*. FAF1 regulates antiviral immunity by inhibiting MAVS but is antagonized by phosphorylation upon viral infection. Cell Host & Microbe. 2018
·      Gao L, Wang L, Dai T, Jin K, Zhang Z, et al., Zhou F*, Zhang L*. Tumor-derived exosome antagonize innate antiviral immunity. Nature Immunology. 2018
·      Zhang M, Jin K, Gao L, Zhang Z, Li F,  Zhou F*, Zhang L*. Methods and technologies for exosome isolation and characterization.  Small Methods. 2018
·      Yan X*, Zhang L*. A special issue on TGF-β signaling: regulation, crosstalk and biology.  Acta Biochim Biophy Sin. 2018
·      Zhang Q, Han X, Chen J, Xie X, Xu J, Zhao Y, Shen J, Hu L, Xu P, Song H, Zhang L, Zhao B, Wang YJ, Xia Z. Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding   motif (TAZ) mediate cell-density-dependent proinflammatory response.  J Biol Chem. 2018
·      Loss of Par3 promotes prostatic tumorigenesis by enhancing cell growth and changing cell division models. Zhou PJ, Wang X, An N, Wei L, Zhang L, Huang X, Zhu HH, Fang YX, Gao WQ. Oncogene. 2018
·      Wang S, Xie F, Chu F, Zhang Z, Yang B, Dai T, Gao L, Wang L, Ling L, Jia J, van Dam H, Jin J, Zhang L*, Zhou F*. YAP antagonizes innate antiviral immunity and is targeted for lysosomal degradation through kinase-IKKe mediated phosphorylation. Nature Immunology. 2017
·      Zhang Z, Fan Y, Xie F, Shao L, et al., Jin J, Ding C, Sheng Y, Zhou F, Zhang L*. Breast cancer metastasis suppressor OTUD1 deubiquitylates SMAD7.  Nature Communications. 2017
·         Xie F, Jin K, Shao L, Fan Y, Tu YF, Yang B, van Dam H, Ten Dijke P, Weng HL, Dooley S, Wang S, Jia JL, Jin J, Zhou F*, Zhang L*. FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis. Nature Communications. 2017
·         Zhou F, Xie F, Jin K, Zhang ZK, Clerici M, Gao R, Sixma TK, Huang HZ, van Dinther M, Zhang L*, Ten Dijke P*. USP4 inhibits SMAD4 monoubiquitination and promotes activin and BMP signaling. EMBO Journal. 2017
·         Jin K*, Li T, van Dam H, Zhou F*, Zhang L*. Molecular insight into tumor metastasis: tracing the dominant events. Journal of Pathology. 2017
·         Xie F, Ling L, van Dam H, Zhou F*, Zhang L*. TGF-β signaling in cancer metastasis. Acta Biochim Biophy Sin. 2017 
·         Zhang L*, Xie F, Ten Dijke P,Zhang J,Zhou F*. SUMO-triggered ubiquitination of NR4A1 controls macrophage cell death. Cell Death & Differentiation. 2017 
·         Gao Z, Li Y,Wang F, Huang T, Fan K, Zhang Y, Zhong J, Cao Q, Chao T, Jia J, Yang S, Zhang L, Xiao Y, Zhou J, Feng X, J Jin. Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability.  Nature Communications. 2017
·         Liu K, Xie F, Gao A, Zhang R, Zhang L, Xiao Z, Hu Q, Huang W, Huang Q, Lin B, Zhu J, Wang H, Que J, Lan X. Sox2 regulates multiple malignant processes of breat cancer development through the SOX2/miR-181a-5p, miR-30e-5p/TUSC3 axis. Molecular Cancer 2017 
·         Li Y, Jin K, Gabi W van Pelt, Hans van Dam, Yu X, Wilma E. Mesker, Peter ten Dijke, Zhou F*,  Zhang L*. c-Myb enhances breast cancer invasion and metastasis through Wnt/β-catenin/Axin2 pathway. Cancer Res. 2016 
·         Zhou F*, Li F, Fang PF, Dai T, Yang B, van Dam H, Jia jl, Zheng M, Zhang L*. Ubiquitin-specific Protease 4 Antagonize Osteoblast Differentiation through Dishevelled. J Bone Miner Res. 2016 
·         Jin K*, Li T, Sanchez-Duffhues G, Zhou F*, Zhang L*. Involvement of inflammation and its related microRNAs in hepatocellular carcinoma. Oncotarget. 2016 
·         Zhang L, Zhou F, van Dinther M, Ten Dijke P. Determing TGF-β Receptor levels in the Cell Membrane Methods Mol Biol. 2016
·         Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).Klionsky DJ, et al., Zhang L, et al., Autophagy. 2016 
·         Li Y, Drabsch Y, Pujuquet P, Ren J, van Laar T, Zhang L, van Dam H, Clement-Lacroix P, Ten Dijke P. Genetic depletion and pharmacological targeting of alphav integrin in breast cancer cells impairs metastasis in zebrafish and mouse xenograft models. Breast Cancer Res. 2015 Feb 25
·         Chen F, Chen J, Lin J, Cheltsov AV, Xu L, Chen Y, Zeng Z, Chen L, Huang M, Hu M, Ye X, Zhou Y, Wang G, Su Y, Zhang L, Zhou F, Zhang XK, Zhou H. NSC-640358 acts as RXRα ligand to promote TNFα-mediated apoptosis of cancer cell. Protein Cell. 2015 Sep
·         Xie F, Zhang Z, van Dam H, Zhang L*, Zhou F*. Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination. Cells. 2014 Oct 
·         Zhou F, Li F, Xie F, Zhang Z, Huang H, Zhang L*. TRAF4 mediates activation of TGF-β signaling and is a biomarker for oncogenesis in breast cancer. Sci China Life Sci. 2014 Dec 
·         Zhang J, Zhang X, Xie F, Zhang Z, van Dam H, Zhang L*, Zhou F*. The regulation of TGF-β/SMAD signaling by protein deubiquitination. Protein Cell. 2014 Apr
·         Zhou F, Drabsch Y, Dekker TJ, de Vinuesa AG, Li Y, Hawinkels LJ,  Sheppard KA, Goumans MJ, Luwor RB, de Vries CJ, Mesker WE, Tollenaar RA,  Devilee P, Lu CX, Zhu H, Zhang L*, Dijke PT*. Nuclear receptor NR4A1  promotes breast cancer invasion and metastasis by activating TGF-β  signalling.  Nat Communications. 2014 
·         Zhang L*, Zhou F*, Ten Dijke P*. Signaling interplay between TGF-β receptor and PI3K/AKT pathway in cancer. Trends in Biochemical Sciences. 2013 Nov
·         Drabsch Y, He S, Zhang L, Snaar-Jagalska BE, Ten Dijke P. Transforming growth factor beta signalling controls human breast cancer metastasis in a zebrafish xenograft model. Breast Cancer Research. 2013 Nov
·        Zhang L#, Zhou F#, García de Vinuesa A, de Kruijf EM, Mesker WE, Hui L, Drabsch Y, Li Y, Bauer A, Rousseau A, Sheppard KA, Mickanin C, Kuppen PJ, Lu CX, Ten Dijke P. TRAF4 Promotes TGF-β Receptor Signaling and Drives Breast Cancer Metastasis. Molecular Cell. 2013 Sep 
·         Zhang X, Zhang J, Bauer A, Zhang L, Selinger DW, Lu CX, and ten Dijke P. Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6. EMBO Journal. 2013
·         Zhang X, Zhang J, Zhang L, van Dam H, Ten Dijke P. UBE2O negatively regulates TRAF6-mediated NF-κB activation by inhibiting TRAF6 polyubiquitination. Cell Research. 2013
·         Zhang L#, Zhou F#, Drabsch Y, Snaar-Jagalska E, Mickanin C, Huang H, Sheppard KA, Lu C, and ten Dijke P. USP4 is regulated by Akt phosphorylation and directly deubiquitinates TGF-βtype I receptor. Nature Cell Biology 2012
·         Zhang L#*, Huang H#, Zhou F#, Pardo CG, Zhang T, Barakat TS, Sheppard KA, van Dam H, Gribnau J, Lu C, and ten Dijke P*. RNF12 controls embryonic stem cell fate and morphogenesis in zebrafish embryos by targeting Smad7 for degradation. Molecular Cell 2012
·         Zhou F, Kai Gong, Yandao Gong and Zhang L*. APP intracellular domain (AICD) inhibits Wnt signaling and promotes neurite outgrowth. BBA-Molecular Cell Research 2012
·         Zhang, J, Zhang X-f, Zhang L, Zhou F, van Dinther M, ten Dijke P. LRP8 mediates Wnt/β-catenin signaling and controls osteoblast differentiation. J. Bone Min Res. 2012
·         Zhang L#, Zhou F#, Li Y, Drabsch Y, Zhang J, van Dam H, Ten Dijke P.Fas-associated factor 1 is a scaffold protein that promotes β-TrCP mediated β-catenin ubiquitination and degradation. J Biol Chem. 2012
·         Gong K, Zhou F, Huang HZ, Gong YD, Zhang L*. Suppression of GSK3β by ERK mediates lipopolysaccharide induced cell migration in macrophage through β-catenin signaling. Protein Cell. 2012
·         Zhou F#, Zhang L#*, van Laar T, van Dam H, ten Dijke P*. GSK3β inactivation induces apoptosis of leukemia cells by repressing the function of c-Myb. Mol Biol Cell. 2011
·         Zhou F, Zhang XF, van Dam H, ten Dijke P, Huang HZ*, Zhang L*.Ubiquitin-specific protease 4 mitigates Toll-like/Interleukin-1 receptor signaling and regulates innate immune activation. J Biol Chem. 2012
·         Zhang L#, Shi S, Zhang J, Zhou F, ten Dijke P. Wnt/β-catenin signaling changes C2C12 myoblast proliferation and differentiation by inducing Id3 expression. Biochem Biophys Res Commun. 2012
·         Zhou F, Huang H, Zhang L*. Bisindoylmaleimide I enhances osteogenic differentiation. Protein Cell. 2012
·         Guidelines for the use and interpretation of assays for monitoring autophagy. Klionsky DJ, Zhang L　et al. Autophagy. 2012
·         Zhang L#, Zhou F#, van Laar T, Zhang J, van Dam H, ten Dijke P. Fas-associated factor 1 antagonizes Wnt signaling by promoting β-catenin degradation. Mol Biol Cell. 2011
·         Zhou F, van Laar T, Huang HZ, Zhang L*. APP and APLP1 are degradated through autophagy in response to proteasome inhibition in neuronal cells. Protein Cell. 2011
·         Zhou F; Gong K; van Laar T; Gong Y, Zhang L*. Wnt/β-catenin signal pathway stabilizes APP intracellular domain (AICD) and promotes its transcriptional activity. Biochem Biophys Res Commun. 2011
·         Yan X, Zhang J, Pan L, Wang P, Xue H, Zhang L, Gao X, Zhao X, Ning Y, Chen YG TSC-22 promotes TGF-β-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity. Mol Cell Biol. 2011
·         Geng Y, Dong Y, Yu M, Zhang L, Yan X, Sun J, Qiao L, Geng H, Nakajima M, Furuichi T, Ikegawa S, Gao X, Chen YG, Jiang D, Ning W. Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development. Proc Natl Acad Sci USA. 2011
·         Zhou F#, Zhang L#, Gong K, Lu G, Sheng B, Wang A, Zhao N, Zhang X, Gong Y. LEF-1 activates the transcription of E2F1. Biochem Biophys Res Commun. 2008
·         Zhou F#, Zhang L#, Wang A, Song B, Gong K, Zhang L, Hu M, Zhang X, Zhao N, Gong. The association of GSK3β with E2F1 facilitates nerve growth factor-induced neural cell differentiation. J Biol Chem. 2008
·         Gao X, Wen J, Zhang L, Li X, Ning Y, Meng A, Chen YG. Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus. J Biol Chem. 2008
·         Su Y#, Zhang L#, Gao X, Meng F, Wen J, Zhou H, Meng A, Chen YG. The evolutionally conserved activity of Dapper2 in antagonizing TGF-β signaling. FASEB J. 2007
·         Chen YG, Wang Z, Ma J, Zhang L, Lu Z. Endofin, a FYVE domain protein, interacts with Smad4 and facilitates transforming growth factor-β signaling. J Biol Chem. 2007
·         Zhang L, Zhang SP, Gao X, Wen J, Chen YG. Modulation of TGFβ -signaling in the cytoplasm and the nucleus. Cell Research 16:S131-S157; (Meeting Abstract)
·         Zhang L, Gao X, Wen J, Ning Y, Chen YG. Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation. J Biol Chem. 2006
·         Gu Y, Jin P, Zhang L, Zhao X, Gao X, Ning Y, Meng A, Chen YG. Functional analysis of mutations in the kinase domain of the TGF-β receptor ALK1 reveals different mechanisms for induction of hereditary hemorrhagic telangiectasia. Blood. 2006
·         Zhang L, Zhou H, Su Y, Sun Z, Zhang H, Zhang L, Zhang Y, Ning Y, Chen YG, Meng A. Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors. Science 2004;

 


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