Regulation of TGF-β signaling by protein phosphatases

时间:2010年09月01日 访问次数:1365

Biochem J. 2010 Sep 1;430(2):191-8.

Ting Liu* , Xin-Hua Feng*


Tight regulation of TGF-β (transforming growth factor-β)superfamily signalling is important for normal cellular functions and tissue homoeostasis. Since TGF-β superfamily signalling pathways are activated by a short phosphorylation cascade, from receptor phosphorylation to subsequent phosphorylation and activation of downstream signal transducer R-Smads (receptor-activated Smads), reversible phosphorylation serves as a critical step to assure proper TGF-β signalling. The present article will review the current progress on the understanding of dynamic phosphorylation in TGF-β signalling and the essential role of protein phosphatases in this process.