报告题目： Biochemical Dissection of Bacterial Virulence and Macrophage Innate Immunity
报告人： Dr. Feng Shao
Investigator, NIBS
HHMI International Early Career Scientist
主持人： 冯新华 教授
时 间： 2012年10月29日（星期一）下午4点
地 点： 医学院综合楼205报告厅
Abstract:
Many bacterial pathogens use a type III secretion system to inject virulent effector proteins into host cells to manipulate host signal transduction pathways. I will present our work on three bacterial effector families that induce three novel enzymatic posttranslational modifications on key host signaling proteins, including eliminylation modification of MAPKs, glutamine deamidation of ubiquitin/NEDD8, cysteine methylation of host NF-κB-pathway ubiquitin-chain sensory proteins TAB2/3. I will also discuss our recent identification and characterization of the NAIP family of NOD-like proteins (NLRs) that serves as innate immune inflammasome receptors for bacterial flagellin as well as the type III secretion apparatus in macrophages.
Many bacterial pathogens use a type III secretion system to inject virulent effector proteins into host cells to manipulate host signal transduction pathways. I will present our work on three bacterial effector families that induce three novel enzymatic posttranslational modifications on key host signaling proteins, including eliminylation modification of MAPKs, glutamine deamidation of ubiquitin/NEDD8, cysteine methylation of host NF-κB-pathway ubiquitin-chain sensory proteins TAB2/3. I will also discuss our recent identification and characterization of the NAIP family of NOD-like proteins (NLRs) that serves as innate immune inflammasome receptors for bacterial flagellin as well as the type III secretion apparatus in macrophages.
