报告人：Hugo J. Bellen, D.V.M., Ph.D.
Investigator, HHMI
Director, Graduate Program in Developmental Biology
Professor, Departments of Molecular and Human Genetics and Neuroscience, Baylor College of Medicine
主持人：佟 超 教授
地 点： 医学院综合楼205报告厅
主持人：佟 超 教授
地 点： 医学院综合楼205报告厅
报告题目1：Altered Mitochondrial Function and Dynamics Induces Neurodegeneration
时 间：2012年10月30日（星期二）下午3点
时 间：2012年10月30日（星期二）下午3点
报告题目2：Phototransduction: Traficking of Rhodopsin and Photoreceptor Degeneration
时 间：2012年10月31日（星期三）下午4点
Selected Publications:
1. Tsuda, H., Jafar-Nejad, H., Patel, A.J.,Sun,Y.,Chen, H.K.,Rose, M.F., Venken,K.J.T., Botas, J.,Orr, H.T.,Bellen, H.J. and Zoghbi,H.Y. 2005. The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins. Cell 122:633-634.
2. Venken, K.J.T., He, Y., Hoskins, R.A. and Bellen, H.J. 2006. P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster. Science 314:1747-1751.
3. Acar, M., Jafar-Nejad, H., Takeuchi, H., Rajan, A., Ibrani, D., Rana, N.A., Pan, H., Haltiwanger, R.S. and Bellen, H.J. 2008. Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling. Cell 132:247-258.
4.Zhai, R.G., Zhang, F., Hiesinger, P.R., Cao, Y., Haueter, C.M. and Bellen, H.J. 2008. NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration. Nature 452:887-891.
5.Tsuda, H., Han, S.M., Yang, Y., Tong, C., Lin, Y.Q., Mohan, K., Haueter, C., Zoghbi, A., Harati, Y., Kwan, J., Miller, M.A. and Bellen, H.J. 2008. The Amyotrophic Lateral Sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors. Cell 133:949-951.
6.Yao, C.K., Lin, Y.Q., Ly, C.V., Ohyama, T., Haueter, C.M., Moiseenkova-Bell, V.Y., Wensel, T.G. and Bellen H.J. 2009. A synaptic vesicle associated Ca2+ channel promotes endocytosis and couples exocytosis to endocytosis. Cell 138:947-960.
7.Neely, G.G., Hess, A., Costigan, M., Keene, A.C., Belfer, I., Dai, F., Gupta, V., Xia, C.P, Amann, S., Kreitz, S., Heindl-Erdmann, C., Ly, C.V., Suchir Arora, S., Sarangi, R., Dan, D., Novatchkova, M., Rosenzweig, M., Truong, D., Schramek, D., Zoranovic, T., Cronin, S., Angjeli, B., Brune, K., Dietzl, G., Pospisilik, J.A., Meixner, A., Thomas, W., Subramaniam, S., Garrity, P.A., Bellen, H.J., Woolf, C.J. and Penninger, J.M. 2010. The calcium channel subunit α2δ3 controls central processing of thermal perception and sensory cross-activation. Cell 143:628-638.
8.The modENCODE Consortium, et al. 2010. Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science 330: 1787-1797.
9.Nègre, N., Brown, C.D., Ma, L., Bristow, C.A., Miller, S.W., Wagner, U., Kheradpour, P., Eaton, M.L., Loriaux, P., Sealfon, R., Li, Z., Ishii, H., Spokony, R.F., Chen, J., Hwang, L., Cheng, C., Auburn, R.P., Davis, M.B., Domanus, M., Shah, P.K., Morrison, C.A., Zieba, J., Suchy, S., Senderowicz, L., Victorsen, A., Bild, N.A., Grundstad, A.J., Hanley, D., MacAlpine, D.M., Mannervik, M., Venken, K., Bellen, H., White, R., Gerstein, M., Russell, S., Grossman, R.L., Ren, B., Posakony, J.W., Kellis, M. and White, K.P. 2011. A cis-regulatory map of the Drosophila genome. Nature 471:527-531.
10.Xue, M., Giagtzoglou, N. and Bellen, H.J. 2011. Dueling Ca2+ sensors in neurotransmitter release. Cell 147:491-493.
