报告题目：从表观遗传学到基因组学：一位女性科学家在性别研究领域的职业发展历程
报告人：Jennifer Marshall Graves 教授
主持人：周 琦 教授
时 间：2023年10月24日（周二）下午4点
地 点：生科楼245报告厅
报告人简介：
Jennifer Marshall Graves教授于1964年获澳大利亚阿德莱德大学遗传学与物理化学学士学位，于1967年获澳大利亚阿德莱德大学遗传学硕士学位，并于1971年获加州大学伯克利分校分子生物学博士学位，现为澳大利亚La Trobe大学杰出教授，并在澳大利亚国立大学、堪培拉大学和墨尔本大学担任荣誉职位。
Jennifer Marshall Graves教授现已入选澳大利亚科学院院士和美国国家科学院外籍院士。曾获欧莱雅-联合国教科文组织杰出女科学家奖，澳大利亚勋章，澳大利亚总理科学奖（澳大利亚最高科学奖项）等奖项。
Jennifer Marshall Graves教授长期从事性别决定和性染色体演化方面的工作，至今已在Nature、Science、Cell、PNAS等国际著名期刊发表研究论文462篇（h-index=86)，培养超过70名博士和博士后，领导了多个国际哺乳类基因组研究联盟。
Abstract:
I fell in love with sex chromosomes early in my 60-year career. They cause so many problems and break all the rules of evolution. I started on X chromosome inactivation, which equalizes gene dosage between XX women and XY men by epigenetic silencing of one X in women. This led to an interest in gene mapping and ultimately sequencing many werid Australian mammals to piece together how human sex chromosomes evolved from an ordinary pair of chromosomes, and how the Y chromosome determines sex. Now I work on sex determination in reptiles, some of which have no sex chromosomes but determine sex using environmental cues – so now I am back studying epigenetic mechanisms that lizards share with mammalian X chromosome inactivation.
Many things have changed in the world of science since I began my career, not the least the recognition that women should play a much greater part and take on leadership roles in science. I have learned many lessons – both personal and professional – about negotiating the hurdles and barriers that hold back women in science. My CV might look as if I were following a grand plan, but like many women in science, my career path has been up and down, dodging academic blockades, interweaving science with family joys and sorrows and taking in many outside interests (music is a big one). Many life decisions were complete accidents or unexpected opportunities. Now at 80 all my interests seem to be coming together – genetics and epigenetics, sex and evolution, even science and music.
