报告题目：Development of next-generation T cell-based immunotherapy
报告人：吴 鹏 教授
主持人：林世贤 研究员
时 间：2025年2月27日（周四）下午2:30
地 点：纳米楼457报告厅
报告人简介：
Dr. Peng Wu received his doctorate from the Scripps Research Institute in 2005 under the guidance of Professor K. Barry Sharpless. From August 2005 to September 2008, he was a postdoctoral fellow in the group of Professor Carolyn R. Bertozzi at the University of California, Berkeley. Dr. Wu's graduate and postdoctoral studies with Prof. Sharpless and Bertozzi laid the foundation for the development of click chemistry and biorthogonal chemistry, which was recognized by the 2022 Nobel Prize in Chemistry. At Berkeley, he combined his interests in bioorthogonal chemistry and biotechnology by developing a method for site-specific modification of monoclonal antibodies using a genetically encoded aldehyde tag. This technology was licensed to Catalent Biologics and developed into a platform that is now known as the SMARTAG®. The research in the Wu lab integrates synthetic chemistry with glycobiology to explore the cellular and molecular mechanisms that control immune responses toward cancer and human pathogens. FucoID, a genetic engineering-free labeling technique developed by the Wu lab, provides the first technology to identify the entire repertoire of tumor antigen-specific T cells for cancer immunotherapy. His recent prized include the ACS Horace S. Isbell Award in 2020, the RSC Horizon Prize in 2021 and the SFG Glycobiology Significant Achievement Award in 2021.
Abstract:
The development of adoptive cell transfer and immune checkpoint inhibitor-based therapies has revolutionized cancer treatment. However, more than 50% of cancer patients fail to respond to these therapies. In this talk, I will discuss our recent progress in the development of new approaches to enhance T cell infiltration into solid tumors. I will also discuss the development of bispecific T cell engager-sialidase fusion proteins to selectively remove sialylated glycans that are upregulated in solid tumors for enhanced tumor control.
