报告题目：Harnessing the healing power of macrophages
报告人：Laszlo Nagy  教授 
主持人：冯新华  教授
时   间：2026年5月14日（周四）下午4点
地   点：纳米楼457报告厅 
报告人简介：

Laszlo Nagy, M.D., Ph.D., is currently Professor of Medicine and Biological Chemistry, Associate Director of the Center for Metabolic Origins of Disease at Johns Hopkins University School of Medicine, Adjunct Professor of Biochemistry and Molecular Biology at the University of Debrecen, Collaborative Professor at the University of South Florida, and Director of the Institute for Fundamental Biomedical Research at Johns Hopkins All Children’s Hospital. He earned his M.D. and Ph.D. (both summa cum laude) from the University of Debrecen, completed postdoctoral training at the University of Texas Houston Medical School, the Salk Institute for Biological Studies, and served as a Howard Hughes Medical Institute Postdoctoral Fellow. Prior to joining Johns Hopkins, he held faculty positions at the University of Debrecen, founded the Center for Clinical Genomics and Personalized Medicine there, and served as Founding Director of the Genomic Control of Metabolism Program at Sanford Burnham Prebys Medical Discovery Institute.

The Nagy lab focuses on deciphering how lipid signaling regulates gene expression and how dynamic lipid environments shape genome activity and cell identity, with particular emphasis on nuclear hormone receptor-mediated transcriptional and epigenomic control in innate immune cells. His work integrates cellular and animal models with multi-omics approaches including epigenomics, lipidomics and spatiotemporal transcriptomics to map regulatory networks governing macrophage polarization, function and crosstalk with other cell types in health and disease. Current research priorities include: (1) Epigenomic and transcriptional mechanisms of macrophage plasticity in tissue repair, skeletal muscle regeneration and metabolic inflammation; (2) Nuclear receptor (especially PPARγ and RXR) signaling in innate immunity, chronic inflammatory disorders and degenerative muscle diseases such as Duchenne muscular dystrophy; (3) Lipid mediator networks and heme homeostasis in myeloid cell function and disease pathogenesis; (4) Identification of therapeutic targets for chronic inflammation, metabolic disease and tissue injury. He has published over 150 peer-reviewed articles, holds multiple patents on nuclear receptor modulators, and has received numerous honors including membership in the Hungarian Academy of Sciences, Academia Europaea, the Henry Kunkel Society, and the EMBO Membership. He also serves on editorial boards of leading journals including FEBS Letters,Cell Death and Disease and Journal of Clinical Investigation, and has led multiple international research consortia and conferences in the fields of nuclear receptor biology, immunometabolism and macrophage biology.