报告人：Julie Ahringer  院士
主持人：赵  斌  教授
时   间：2026年7月23日（周四）
地   点：校友楼紫金港厅 
报告人简介：

Julie Ahringer，英国剑桥大学遗传学与基因组学教授、Gurdon研究所资深课题组组长及Wellcome Investigator。她长期以秀丽隐杆线虫（Caenorhabditis elegans）为模式生物，研究基因调控、染色质组织及发育机制，并率先开展动物全基因组RNA干扰筛选，推动了功能基因组学和大规模反向遗传学的发展。其研究成果发表于 Nature、Nature Cell Biology、Nature Genetics、eLife等国际权威期刊。

Ahringer 教授是欧洲分子生物学组织（EMBO）成员、英国医学科学院院士及英国皇家学会会士（FRS），曾获英国皇家学会 Francis Crick Lecture Prize 和美国遗传学学会 George W. Beadle Award 等重要荣誉。

报告摘要：

Multimodal single-cell profiling provides a powerful approach for unravelling the gene regulatory mechanisms that drive development, by simultaneously capturing cell-type-specific transcriptional and chromatin states. However, its inherently destructive nature hampers the ability to trace regulatory dynamics between mother and daughter cells. Taking advantage of the invariant cell lineage of Caenorhabditis elegans, we constructed a lineage-resolved single-cell multimodal map of development up to gastrulation, which allows the tracing of chromatin accessibility and gene expression changes across cell divisions and regulatory cascades. Through analysing the map, we find that zygotic transcription begins on a pre-patterned accessible chromatin landscape, identified regulators that drive zygotic genome activation, and defined transcriptional cascades during early lineage specification. Our findings demonstrate the power of a lineage-resolved atlas for dissecting the genome regulatory events of development.