报告题目：Necroptosis signaling and its physiological functions
报告人：孙丽明  研究员 
主持人：焦会朋  研究员
时   间：2023 年4月26日（周三）上午10点
地   点：纳米楼457报告厅
报告人简介：

Liming Sun, Ph.D., is a professor at Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences. Her research primarily focused on the molecular mechanism of necroptosis signaling, and its relevance to human diseases. Her major scientific contributions include: (1) Discovered MLKL as a key component of necroptosis pathway at the downstream of RIP3; (2) Identified the autophosphorylation site on RIP3, which is required for MLKL recruitment; (3) Identified the phosphorylation sites on MLKL that are catalyzed by RIP3, which are required for releasing its autoinhibition; (4) Screened out new necroptosis inhibitor NSA, and defined its targeting site on human MLKL-Cys86; (5) Developed monoclonal antibodies that specifically recognize p-RIP3 or p-MLKL, which potentially serve as important tools to dissect necroptosis signaling in vivo; (6) Found microtubule-targeting agents (MTAs) utilize membrane bound-TNF to kill the adjacent tumor cells, which reframed our fundamental understanding on how MTA drugs utilize the tight contact between solid tumor cells to induce cancer-cell-to-cancer-cell killing and eventually shrink the entire tumor with “snowball” effect; (7) Identified Tenascin-C (TNC), released by necroptotic myofibers, as a key factor to promote muscle stem cell (MuSC) proliferation through directly stimulating EGF receptor (EGFR) cascade in MuSCs during regeneration, which provided us a paradigm for understanding that necroptosis, as a form of “altruistic suicide”, contributing the conditional niche for adult stem cell proliferation upon injury; (8) Identified a novel phosphorylation site of MLKL that blocks necroptosis-induced systemic inflammation during mouse development, which provided the direct evidence that the spontaneous activation of necroptosis and the potential non-cell death role of MLKL during development. She has published a series of research papers in journals such as Cell, Cell Research, PNAS, and Cell Death & Differ as the first author or corresponding author. She is the recipient of National Science Fund for Excellent Young Scholars, Outstanding Young Scientists Award of Chinese Academy of Sciences,Shanghai Youth Talent Support Program, Shanghai Rising-Star and 100 Talents Program of CAS, S Category. She serves as the Editorial board member of Cell Death & Dis and Communications Biology, and Secretary-general of Chinese society for cell death research, CSCB.