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Representative publications (* denotes corresponding author)

1.     Zhang, R.#, Pan, S. #, Zheng, S. #,  Liao, Q., Jiang Z., Wang, D., Li, X., Hu, A., Li, X., Zhu, Y., Shen,  X., Lei, J., Zhong, S., Zhang, X., Huang, L., Wang, X., Huang, L., Shen,  L., Song, B.-L., Zhao, J., Wang, Z., Yang, B.*, and Guo, X.* Lipid-anchored Proteasomes Control Membrane Protein Homeostasis. Science Advances (in press)

2.      Wang, G. #, Lei, J. #, Wang, Y., Yu, J., He, Y., Zhao, W., Hu, Z., Xu, Z., Jin, Y., Gu, Y., Guo, X.,  Yang, B., Gao, Z. and Wang, Z.* The ZSWIM8 ubiquitin ligase regulates  neurodevelopment by guarding the protein quality of intrinsically  disordered Dab1. Cereb Cortex, 2023. 33:3866-3881

3.      Kong, X., Shu, X., Wang, J., Liu, D., Ni, Y., Zhao, W., Wang, L., Gao, Z., Chen, J., Yang, B.*, Guo, X.*, and Wang, Z.* Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development. Development, 2022. 149:dev201286.

4.      Guo, X.* Localized Proteasomal Degradation: From the Nucleus to Cell Periphery. Biomolecules, 2022.12:229-244.

5.      Duan, J., Li, W., Shu, X., Yang, B., He, X., and Guo, X.* Conserved mitotic phosphorylation of a proteasome subunit regulates cell proliferation. Cells, 2021. 10:3075.

6.      Shi, L.#, Liu, B.#,  Shen, D.-d., Yan, P., Zhang, Y., Tian, Y., Hou, L., Jiang, G., Zhu, Y.,  Liang, Y., Liang, X., Shen, B., Yu, H., Zhang, Y., Wang, Y.*, Guo, X.*, and Cai, X.*, A tumor-suppressive circular RNA mediates uncanonical integrin degradation by the proteasome in liver cancer.Science Advances, 2021. 7(13): eabe5043.

7.      Chen, L. #, Zhang, Y. #,  Shu, X., Chen, Q., Wei, T., Wang, H., Wang, X., Wu, Q., Zhang, X., Liu,  X., Zheng, S., Huang, L., Xiao, J., Jiang, C., Yang, B., Wang, Z.*, and Guo, X.*, Proteasome regulation by reversible tyrosine phosphorylation at the membrane.Oncogene, 2021. 40:1942-1956.

8.      Liu, X. #, Xiao, W. #,  Zhang, Y., Wiley, S.E., Zuo, T., Zheng, Y., Chen, N., Chen, L., Wang,  X., Zheng, Y., Huang, L., Lin, S., Murphy, A.N., Dixon, J.E., Xu, P.,  and Guo, X.*, Reversible phosphorylation of Rpn1 regulates 26S proteasome assembly and function.Proc Natl Acad Sci U S A, 2020. 117(1): 328-336.

9.      Fan, K., Wang, F., Li, Y., Chen, L., Gao, Z., Zhang, Y., Duan, J.Y., Huang, T., Zhong, J., Liu, R.B., Mao, X., Fan, H., Guo, X.*, and Jin, J.*, CRL4DCAF2 is required for mature T-cell expansion via Aurora B-regulated proteasome activity.J Autoimmun, 2019. 96: 74-85.

10.  Banerjee, S. #, Ji, C. #, Mayfield, J.E., Goel, A., Xiao, J., Dixon, J.E.*, and Guo, X.*, Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2.Proc Natl Acad Sci U S A, 2018. 115(32): 8155-8160.

11.  Guo, X.*, Huang, X., and Chen, M.J., Reversible phosphorylation of the 26S proteasome.Protein Cell, 2017. 8(4): 255-272.

12.  Chen, Y., Zhang, Y., and Guo, X.*, Proteasome dysregulation in human cancer: implications for clinical therapies.Cancer Metastasis Rev, 2017. 36(4): 703-716.

13.  Guo, X.*, Wang, X., Wang, Z., Banerjee, S., Yang, J., Huang, L., and Dixon, J.E.*, Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis.Nat Cell Biol, 2016. 18(2): 202-212.

14.  Guo, X.* and Dixon, J.E.*, The 26S proteasome: A cell cycle regulator regulated by cell cycle.Cell Cycle, 2016. 15(7): 875-876.

15.  Guo, X., Engel, J.L., Xiao, J., Tagliabracci, V.S., Wang, X., Huang, L., and Dixon, J.E.*, UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity.Proc Natl Acad Sci U S A, 2011. 108(46): 18649-18654.


Other publications

16.   Wei, T. #, Wang, J. #, Liang, R. #, Chen, W., Chen, Y., Ma, M., He, A., Du, Y., Zhou, W., Zhang, Z., Zeng, X., Wang, C., Lu, J., Guo, X., Chen, X.W., Wang, Y., Tian, R., Xiao, J., and Lei, X. Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife, 2022.11:e77696.

17.   Wei, X., Zhao, L., Ren, R., Ji, F., Xue, S., Zhang, J., Liu, Z., Ma, Z., Wang, X.W., Wong, L., Liu, N., Shi, J., Guo, X., Roessler,  S., Zheng, X., Ji, J.. MiR-125b Loss Activated HIF1α/pAKT Loop, Leading  to Trans-Arterial Chemoembolization Resistance in Hepatocellular  Carcinoma. Hepatology, 2021. 73(4):1381-1398

18.  Yan, F., Huang, C., Wang, X., Tan, J., Cheng, S., Wan, M., Wang, Z., Wang, S., Luo, S., Li, A., Guo, X.,  Feng, M., Liu, X., Zhu, Y., Zhou, Y. Threonine ADP-Ribosylation of  Ubiquitin by a Bacterial Effector Family Blocks Host Ubiquitination. Mol Cell, 2020. 78(4):641-652.

19.  Ma, XJ., Chen, X., Jin, Y., Ge, WY., Wang, WY., Kong, LH., Ji, JF., Guo, X.,  Huang, J., Feng, XH,, Fu, JF., Zhu, SY. Small molecules promote  CRISPR-Cpf1-mediated genome editing in human pluripotent stem cells. Nat Comm, 2018. 9:1303.

20.  Zhang, H., Zhu, Q., Cui, J., Wang, Y., Chen, M. J., Guo, X., Tagliabracci, V. S., Dixon, J. E. & Xiao, J. Structure and evolution of the Fam20 kinases. Nat Comm, 2018. 9:1218.

21.  Wang,  X., Cimermancic, P., Yu, C., Schweitzer, A., Chopra, N., Engel, J.L.,  Greenberg, C., Huszagh, A.S., Beck, F., Sakata, E., Yang, Y., Novitsky,  E.J., Leitner, A., Nanni, P., Kahraman, A., Guo, X.,  Dixon, J.E., Rychnovsky, S.D., Aebersold, R., Baumeister, W., Sali, A.,  and Huang, L. Molecular Details Underlying Dynamic Structures and  Regulation of the Human 26S Proteasome. Mol Cell Proteomics, 2017. 16:840-854.

22.  He, Y., Guo, X.,  Yu, Z.-H., Wu, L., Gunawan, A.M., Zhang, Y., Dixon, J.E., and Zhang,  Z.-Y. A potent and selective inhibitor for the UBLCP1 proteasome  phosphatase. Bioorg Med Chem, 2015. 23:2798–2809.

23.  Wang, Z., Hou, Y#., Guo, X.#,  van der Voet, M., Boxem, M., Dixon, J.E., Chisholm, A.D. and Jin, Y.  The EBAX-type Cullin-RING E3 Ligase and Hsp90 Guard the Protein Quality  of the SAX-3/Robo Receptor in Developing Neurons. Neuron, 2013. 79:903–916. #Equal contribution

24.  Guo, X.*, and Wang, X.-F*. A P(E)RM(I)T for BMP Signaling. Mol Cell, 2013. 51:1-2.

25.  Guo, X.*, and Wang, X.-F*. A Mediator Lost in the War on Cancer. Cell, 2012. 151:927-929.

26.  Guo, X.*, and Wang X.-F*. New secrets behind bone metastasis. Cell Res, 2012. 22:1309-1311.

27.  Guo, X., Wang X.-F. Signaling cross-talk between TGF-β/BMP and other pathways. Cell Res, 2009. 19:71-88.

28.  Guo, X.#, Waddell,  D. S.#, Wang, W., Wang, Z., Liberati, N. T., Yong, S., Liu X. and Wang  X.-F. Ligand-Dependent Ubiquitination of Smad3 Is Regulated by Casein  Kinase 1 gamma 2 (CKIγ2), An Inhibitor of TGF-β Signaling. Oncogene, 2008. 27:7235–7247. #Equal contribution

29.  Lee Y.-S., Lim K.-H., Guo, X.,  Kawaguchi Y., Gao Y., Barrientos T., Ordentlich P., Wang X.-F., Counter  C. and Yao T.-P. The cytoplasmic deacetylase HDAC6 is required for  efficient oncogenic tumorigenesis. Cancer Res, 2008. 68:7561-7569.

30.  Guo, X.,  Ramirez, A., Waddell, D. S., Li, Z., Liu, X., and Wang, X.-F. Axin and  GSK3-β control Smad3 protein stability and modulate TGF-β signaling. Genes & Dev, 2008. 22:106-120.

31.  Hjelmeland, A. B., Schilling, S. H.,Guo, X.,  Quarles, D., and Wang, X.-F. Loss of Smad3-Mediated Negative Regulation  of Runx2 Activity Leads to an Alteration in Cell Fate Determination. Mol Cell Biol, 2005. 25:9460-9468.

32.  Waddell, D. S., Liberati, N. T., Guo, X.,  Frederick, J. P., and Wang, X.-F. Casein Kinase Iε Plays a Functional  Role in the Transforming Growth Factor-β Signaling Pathway. J. Biol Chem, 2004. 279:29236-29246.

33.  Shao, R., and Guo, X. Human  microvascular endothelial cells immortalized with human telomerase  catalytic protein: a model for the study of in vitro angiogenesis. Biochem Biophys Res Comm, 2004. 321:788-794.

34. Zhou, C., Wen, Z.-X., Wang, Z.-P., Guo, X.,  Shi, D.-M., Zuo, H.-C., and Xie, Z.-P. Green fluorescent  protein-labeled mapping of neural stem cells migrating towards damaged  areas in the adult central nervous system. Cell Biol Inter, 2003. 27:943-945.