曹劲 博士

    浙江大学生命科学研究院 副教授

    电话：86-571-88208038

       Email: jincao@zju.edu.cn

    教育背景                     

    武汉大学生命科学学院  生物学基地班   学士

       Texas A&M University      Medical Science   Ph.D.

工作经历                     

1999~2005武汉大学生命科学学院   技术员

2014~2018         Baylor College of Medicine        Postdoctoral associate

2018~2019          Baylor College of Medicine        Instructor  

2019~浙江大学生命科学研究院     副教授

研究方向                    

   肿瘤生物学

发表论文                    

1. Yuan B, Liu J, Cao J, Yu Y, Zhang H, Wang F, Zhu Y, Xiao M, Liu S, Ye Y, Ma L, Xu D, Xu N, Li Y, Zhao B, Xu P, Jin J, Xu J, Chen X, Shen L, Lin X, Feng XH.PTPN3 acts as a tumor suppressor and boosts TGF-beta signaling independent of its phosphatase activity. EMBO J. 2019 Jun 14; [Epub ahead of print]

2. Dong H, Adams NM, Xu YC, Cao J, Allan D.S.J, Carlyle JR, Chen X, Sun JC, Glimcher LH. The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity by regulating c-Myc. Nature Immunology. 2019 Jul;20(7):865-878.

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3. Liu L, Zhao ML, Jin X, Ney G, Yang B, Peng FL, Cao J, Iwawaki T, Valle DJ, Chen X, and Li Q. Adaptive ER stress signaling via IRE1α/XBP1 preserves self-renewal of hematopoietic and pre-leukemic stem cells. Nature Cell Biology.2019 Mar;21(3):328-337

4. Lu Y, Cao J, Napoli M, Xia Z, Zhao N, Creighton C, Chen X, Flores E, McManus, MT, Rosen JM. MiR-205 Regulates Mammary Basal Cell Identity and Stem Cell Regenerative Potential through YAP and Wnt signaling. Stem Cells. 2018 Dec;36(12):1875-1889

5. Lei T, Shao JY, Zhang J, Iglesia M, Chang W, Cao J, Anurag M, Singh P, He XP, Kosaka Y, Matsunuma R, Crowder R, Hoog J, Phommaly C, Goncalves R, Ramalho S, Peres RMR, Punturi N, Schmidt C, Bartram A, Jou E, Lai W, Hampton O, Rogers A, Tobias E, Parikh P, Davies S, Li SQ, Ma X, Suman V, Hunt K, Watson M, Hoadley KA, Thompson EA, Chen X, Kavuri SM, Creighton CJ, Maher C, Perou CM, Haricharan S,  Ellis MJ. Functional annotation of ESR1 gene fusions in estrogen receptor positive breast cancer. Cell Reports. 2018 Aug 7;24(6):1434-1444

6. Xie H, Tang CH, Song J, Mancuso A, Valle JR, Cao J, Xiang Y, Dang CV, Lan R, Sanchez D, Keith B, Hu CC, Simon MC. IRE1 RNase dependent lipid homeostasis promotes survival in Myc-transformed cancers. Journal of Clinical Investigation.2018 Apr 2;128(4):1300-1316.

7. Zhao N¹, Cao J¹ ,Xu LY¹, Tang QZ¹, Dobrolecki L, Lyu XD, Talukdar M, Lu Y, Wang XR, Hu D, Shi Q, Xiang Y, Wang YF, Liu X, Bu W, Jiang Y, Li MZ, Gong YY, Sun Z, Ying HQ, Yuan B, Lin X, Feng XH, Hartig S, Li F, Shen HF, Chen YW, Han L, Xeng QP, Patterson J, Kaipparettu BA, Putluri N, Sicheri F, Rosen J, Lewis MT, Chen X. Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer. Journal of Clinical Investigation.2018 Apr 2;128(4):1283-1299. [Co-first author]

8. Cao J, Yu Y, Zhang Z, Chen X, Hu Z, Tong Q, Chang J, Feng XH, Lin X. SCP4 promotes gluconeogenesis through FoxO1/3a dephosphorylation. Diabetes. 2018 Jan; 67(1):46-57.

9. Yu R, Chen JA, Xu J, Cao J, Wang Y, Thomas SS, Hu Z. Suppression of muscle wasting by the plant-derived compound ursolic acid in a model of chronic kidney disease. J Cachexia Sarcopenia Muscle. 2017 Apr; 8(2):327-341.

10. Peng H, Li Y, Wang C, Zhang J, Chen Y, Chen W, Cao J, Wang Y, Hu Z, Lou T. ROCK1 induces endothelial-to-mesenchymal transition in glomeruli to aggravate albuminuria in diabetic nephropathy. Sci Rep. 2016; 6:20304.

11. Peng H, Cao J, Yu R, Danesh F, Wang Y, Mitch WE, Xu J, Hu Z. CKD stimulates      muscle protein loss via Rho-associated protein kinase 1 activation.J Am Soc Nephrol. 2016 Feb; 27(2):509-19.

12. Mittal A, Balasubramanian R, Cao J, Singh P, Subramanian S, Hicks G, Nothnagel EA, Abidi N, Janda J, Galbraith DW, Rock CD. TOPOISOMERASE 6B is involved in chromatin remodeling associated with control of carbon partitioning into secondary metabolites and cell walls, and epidermal morphogenesis in Arabidopsis. Journal of Experimental Botany. 2014 Aug; 65(15):4217-39.

13. Psychoyos D, Vinod KY, Cao J, Xie S, Hyson RL, Wlodarczyk B, He W, Cooper TB, Hungund BL, Finnell RH. Cannabinoid receptor 1 signaling in embryo neurodevelopment. Birth Defects Res B Dev Reprod Toxicol. 2012 Apr; 95(2):137-50.

14. Luo W, Cao J, Li J, He W. Adipose tissue-specific PPARγ deficiency increases resistance to oxidative stress. Exp Gerontol. 2008 Mar; 43(3):154-63.