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已发表的研究论文:

1. Jiaxing Tan*, Xing Zhang*#, Xiaofei Wang*, Caihuang Xu*, Shenghai Chang, Hangjun Wu, Ting Wang, Huihui Liang, Haichun Gao, Yan Zhou, Yongqun Zhu#. Structural Basis of Assembly and Torque Transmission of the Bacterial Flagellar Motor. Cell. 2021 May 13;184(10):2665-2679.

2. Fujie Yan*, Huang Chunfeng*, Xiaofei Wang*, Jiaxing Tan, Shen Cheng, Muyang Wan, Zhao Wang, Shuangyu Wang, Shuhui Luo, Atong Li, Xing Guo, Mingguang Feng, Xiaoyun Liu, Yongqun Zhu#, Yan Zhou#.Threonine ADP-Ribosylation of Ubiquitin by a Bacterial Effector Family Blocks Host Ubiquitination. Molecular Cell. 2020 May 21;78(4):641-652.e9.

3. Jiaxing Tan, Shuhui Luo, Yan Zhou, Yongqun Zhu#. Modulation of Host Ubiquitination Pathways by Pathogenic Bacterial Effector Proteins. Progress in Biochemistry and Biophysics.  2020,47(02).

4. Muyang Wan*, Xiaofei Wang*, Jiaxing Tang, Fujie Yan, Zhao Wang, Yan Zhou, Yongqun Zhu#. A bacterial effector deubiquitinase specifically hydrolyses linear ubiquitin chains to inhibit host inflammatory signalling.. Nature Microbiology. 2019 Aug;4(8):1282-1293.   (*equal contribution, # corresponding author)

5. Yan Zhou*, Chunfeng Huang*, Li Yin, Muyang Wan, Xiaofei Wang, Lin Li, Yanhua Liu, Zhao Wang, Panhan Fu, Ni Zhang, She Chen, Xiaoyun Liu, Feng Shao, Yongqun Zhu#. Nε-Fatty acylation of Rho GTPases by a MARTX toxin effector. Science. 2017 Oct 27;358(6362):528-531.

6.  Jianpo Xu*, Dandan Xu*, Muyang Wan, Li Yin, Xiaofei Wang, Lijie Wu, Yanhua Liu, Xiaoyun Liu, Yan Zhou, Yongqun Zhu#. Structural insights into the roles of the IcmS-IcmW complex in the type IVb secretion sytem of Legionella pneumophila. Proc Natl Acad Sci USA2017 Dec 19; 114(51): 13543-48.

7.  Muyang Wan, Yan Zhou, Yongqun Zhu#. Subversion of Macrophage Functions by Bacterial Protein Toxins and Effectors. Curr Issues Mol Biol. 2017 Sep 6;25:61-80.

8.  Zhaofeng Yan, Meng Yin, Dandan Xu, Yongqun Zhu#, Xueming Li#. Structural insights into the secretin translocation channel in the type II secretion system. Nature Structural & Molecular Biology.  2017 Jan 9.  (# corresponding authors)

9.  Deli Huang, Xinru Zheng, Zi-An Wang, Xin Chen, Wan-Ting He, Yingying Zhang, Jin-Gen Xu, Hang Zhao, Wenke Shi, Xin Wang, Yongqun Zhu, Jiahuai Han. MLKL channel in necroptosis is octamer formed by tetramers in a dyadic process. Mol Cell Biol. 2016 Dec 5.

10.  Xiaofei Wang*, Deqiang Yao*, Jin-Gen Xu, A-Rong Li, Jianpo Xu, Panhan Fu, Yan Zhou, Yongqun Zhu#. Structural basis of Cas3 inhibition by the bacteriophage protein AcrF3. Nature Structural & Molecular Biology. 2016 Sep;23(9):868-70.

11.  Yan Zhou, Yongqun Zhu#. Diversity of bacterial manipulation of the host ubiquitin pathways. Cellular Microbiology. 2015 Jan;17(1):26-34.

12.  Jin-Gen Xu*, Chunfeng Huang*, Zhengfeng Yang, Mengmeng Jin, Panhan Fu, NiZhang, Jian Luo, Dali Li, Mingyao Liu, Yan Zhou , Yongqun Zhu#. Crystal Structure of LGR4-Rspo1 Complex: Insights into the divergent mechanisms of ligand recognition by Leucine-rich G-protein-coupled receptors (LGRs). Journal of Biological Chemistry. 2015 Jan 23;290(4):2455-65.

13.  Kai Xu K, Chan YP, Bradel-Tretheway B, Akyol-Ataman Z, Yongqun Zhu, Dutta S, Yan L, Feng Y, Wang LF, Skiniotis G, Lee B, Zhou ZH, Broder CC, Aguilar HC, Nikolov DB. Crystal Structure of the Pre-fusion Nipah Virus Fusion Glycoprotein Reveals a Novel Hexamer-of-Trimers Assembly. PLoS Pathogens. 2015 Dec 8;11(12):e1005322.

14.  Panhan Fu*, Xiaoqing Zhang*, Mengmeng Jin*, Li Xu, Chong Wang, Zongping Xia, Yongqun Zhu#. Complex Structure of OspI and Ubc13: The Molecular Basis of Ubc13 Deamidation and Convergence of Bacterial and Host E2 Recognition. PLoS Pathogens. 2013 Apr;9(4):e1003322.

15.  Qing Yu, Liyan Hu, Qing Yao, Yongqun Zhu, Na Dong, Da-Cheng Wang, Feng Shao. Structural analyses of Legionella LepB reveal a new GAP fold that catalytically mimics eukaryotic RasGAP. Cell Research. 2013 Jun;23(6):775-87

16.  Na Dong*, Yongqun Zhu*#, Qiuhe Lu, Liyan Hu, Yuqing Zheng, Feng Shao#.Structurally Distinct Bacterial TBC-like GAPs Link Arf GTPase to Rab1 Inactivation to Counteract Host Defenses. Cell. 2012 Aug 31;150(5):1029-41.

17. Yongqun Zhu, Liyan Hu, Yan Zhou, Qing Yao, and Feng Shao. Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA. Proc Natl Acad Sci USA. 2010 Mar 9; 107(10):4699-704.

18.  Qing Yao, Jixin Cui, Yongqun Zhu, Guolun Wang, Liyan Hu, Chengzu Long, Ran Cao, Xinqi Liu, Niu Huang, She Chen, Liping Liu, and Feng Shao. A bacterial type III effector family uses the papain-like hydrolytic activity to arrest the host cell cycle. Proc Natl Acad Sci USA. 2009 Mar 10; 106(10):3716-21.

19.  Yongqun Zhu, Hongtao Li, Jiayi Wang, Liyan Hu, Yan Zhou, Liping Liu, Feng Shao. Structure of a Shigella effector reveals a new class of ubiquitin ligases. Nature Structural & Molecular Biology. 15(12):1302-8, Dec 2008.

20.  Yongqun Zhu, Hongtao Li,Chengzu Long, Liyan Hu, Hao Xu, Liping Liu, She Chen, Da-Cheng Wang, and Feng Shao. Structural Insights into the Enzymatic Mechanism of the Pathogenic MAPK Phosphothreonine Lyase. Molecular Cell. 28, 899–913, Dec 14, 2007.

21.  Yong-Qun Zhu, De-Yu Zhu, Lei Yin, Ying Zhang, Clemens Vonrhein, and Da-Cheng Wang. Crystal Structure of Human Spermidine/Spermine N1-Acetyltransferase (hSSAT): The First Structure of a New Sequence Family of Transferase Homologous Superfamily. PROTEINS. 63:1127–1131, 2006.

22.  De-Yu Zhu, Yong-Qun Zhu*, Ren-Huai Huang, Ye Xiang, Na Yang, Hong-Xia Lu, Gen-Pei Li, Qi Jin, and Da-Cheng Wang. Crystal Structure of the Copper Homeostasis Protein (CutCm) from Shigella flexneri at 1.7Å Resolution: The First Structure of a New Sequence Family of TIM Barrels. PROTEINS.58:764–768, 2005.

23.  De-Yu Zhu, Yong-Qun Zhu*, Ye Xiang and Da-Cheng Wang. Optimizing Protein Crystal Growth through Dynamic Seeding. Acta Cryst. D (2005). 61, 772-775.

24.  Yong-Qun Zhu, De-Yu Zhu, Hong-Xia Lu, Na Yang, Gen-Pei Li, Da-Cheng Wang. Purification and Preliminary Crystallographic Studies of CutC, a Novel Copper Homeostasis Protein from Shigella flexneri. Protein & Peptide Letters. 12, 823-826, 2005.