Publications (#Co-first author, *Corresponding author)
15. Wang Z, Ying J, Zhang X, Miao C, Xiao Y, Zou J, Chen B*. Small-Molecule Modulation of Protein Lipidation: From Chemical Probes to Therapeutics. ChemBioChem. DOI: 10.1002/cbic.202300071 (2023)
14. Wang Z, Zhang H, Chen B, Ouyang S, Zheng T, Zhou R, Dong Z, Huang Y, Zhang T, Jiang H, Gan J, Luo C*, Yang CG*. A Peptide Binder of E3 Ligase Adaptor SPOP Disrupts Oncogenic SPOP‐Protein Interactions in Kidney Cancer Cells. Chinese Journal of Chemistry 39, 274-280 (2021)
13. Chen B, Wu X*. Probing Substrate Preferences of Depalmitoylases. Cell Chemical Biology 26(1):3-6 (2019).
12. Chen B, Niu J, Kreuzer J, Zheng B, Jarugumilli GK, Haas W, Wu X*. Auto-fatty Acylation of Transcription Factor RFX3 Regulates Ciliogenesis. Proceedings of the National Academy of Sciences of the United States of America 115(36):E8403-E8412 (2018).
11. Chen B, Sun Y, Niu J, Jarugumilli GK, Wu X *. Protein lipidation in cell signaling and diseases: function, regulation and therapeutic opportunities. Cell Chemical Biology 25(7):817-831 (2018).
10. Jarugumilli GK, Choi JR, Chan P, Yu M, Sun Y, Chen B, Niu J, DeRan M, Zheng B, Zoeller R, Lin C, Wu X*. Chemical Probe to Identify the Cellular Targets of the Reactive Lipid Metabolite 2-trans-Hexadecenal. ACS Chemical Biology. 13(5):1130-1136(2018).
9. Chen S, Zhu B, Yin C, Liu W, Han C, Chen B, Liu T, Li X, Chen X, Li C, Hu L, Zhou J, Xu ZX, Gao X, Wu X, Goding CR, Cui R*. Palmitoylation-dependent activation of MC1R prevents melanomagenesis. Nature 549(7672):399-403 (2017).
8. Chen B, Zheng B, DeRan M, Jarugumilli GK, Fu J, Brooks YS, Wu X*. ZDHHC7-Mediated S-Palmitoylation of Scribble Regulates Cell Polarity. Nature Chemical Biology12, 686-693 (2016).
7. Guo ZQ#, Zheng T#, Chen B#, Luo C#, Ouyang S#, Gong S, Li J, Mao LL, Lian F, Yang Y, Huang Y, Li L, Lu J, Zhang B, Zhou L, Ding H, Gao Z, Zhou L, Li G, Zhou R, Chen K, Liu J, Wen Y, Gong L, Ke Y, Yang SD, Qiu XB, Zhang N, Ren J, Zhong D, Yang CG*, Liu J*, Jiang H*. Small-molecule targeting of E3 ligase adaptor SPOP in kidney cancer.Cancer Cell 30, 474-84 (2016).
6. Zheng B, Jarugumilli GK, Chen B, Wu X*. Chemical Probes to Directly Profile Palmitoleoylation of Proteins. Chembiochem 17, 2022-2027 (2016).
5. Chen B, Gan JH*, Yang CG *. The complex structures of ALKBH2 mutants cross-linked to dsDNA reveal the conformational swing of β-hairpin. Science China Chemistry 57, 307-313 (2014). (Cover story).
4. Li X, Song B*, Chen X, Wang Z, Zeng M, Yu D, Hu D, Chen Z, Jin L, Yang S*, Yang C, Chen B. Crystal structure of a four-layer aggregate of engineered TMV CP implies the importance of terminal residues for oligomer assembly. PLoS One 8, e77717 (2013).
3. Chen B#, Ye F#, Yu L#, Jia G, Huang X, Zhang X, Peng S, Chen K, Wang M, Gong S, Zhang R, Yin J, Li H, Yang Y, Liu H, Zhang J, Zhang H, Zhang A, Jiang H, Luo C*, Yang CG*. Development of Cell-active N6-Methyladenosine RNA Demethylase FTO Inhibitor.Journal of the American Chemical Society 134, 17963-71 (2012).
2. Yi C, Chen B, Qi B, Zhang W, Jia G, Zhang L, Li CJ, Dinner AR, Yang CG*, He C*. Duplex interrogation by a direct DNA repair protein in search of base damage. Nature Structural & Molecluar Biology 19, 671-676 (2012). (Cover story).
1. Chen B, Liu H, Sun X, Yang CG*. Mechanistic insight into the recognition of single-stranded and double-stranded DNA substrates by ABH2 and ABH3. Molecular BioSystems6, 2143-49 (2010).
Book chapter
Chen B*, Guarino C, Azzi A, Erb H, Wu X *. ‘Regulation of cell polarity by posttranslational protein palmitoylation’. Methods in Molecular Biology 2438, 107-121 (2022).