Selected from 63 publications:
1. Jin J, Shirogane T, Xu L, Nalepa G, Qin J, Elledge SJ, Harper JW. 2003. SCFβ-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Genes & Development. 17:3062-3074.
2. Welcker M, Orian A, Jin J, Grim JE, Harper JW, Eisenman RN, Clurman BE. 2004. The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Proc. Natl. Acad. Sci. USA 101:9085-9090.
3. Cullinan SB, Gordan JD, Jin J, Harper JW, Diehl JA. 2004. The Keap1-BTB protein Is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: Oxidative stress sensing by a Cul3-Keap1 ligase. Mol. Cell. Biol. 24:8477-8486.
4. Jin J, Cardozo T, Lovering RC, Elledge SJ, Pagano M, Harper JW. 2004. Systematic analysis and nomenclature of mammalian F-box proteins. Genes & Development. 18:2573-2580.
5. Sundqvist A, Bengoechea-Alonso MT, Ye X, Lukiyanchuk V, Jin J, Harper JW, Ericsson J. 2005. Phosphorylation-dependent ubiquitylation and degradation of SREBP1 by the SCF-FBW7 complex. Cell Metabolism. 1:379-391.
6. Wei W, Jin J, Schlisio S, Harper JW, Kaelin WG Jr. 2005. The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase. Cancer Cell. 8:25-33.
7. Jin J, Arias EE, Chen J, Harper JW, Walter JC. 2006. A family of diverse Cul4-Ddb1 interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Molecular Cell. 23:709-721. (Featured Article).
8. Jin J, Li X, Gygi SP, Harper JW. 2007. Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging. Nature. 447:1135-1138. (Editor's choice, Science, Vol. 2007, Issue 393, p. tw238; Research Highlights, Nature Reviews Molecular Cell Biology, 2007, Vol 8, p599).
9. Centore RC, Havens CG, Manning AL, Li JM, Flynn RL, Tse A, Jin J, Dyson NJ, Walter JC, Zou L. 2010. CRL4Cdt2-Mediated Destruction of the Histone Methyltransferase Set8 Prevents Premature Chromatin Compaction in S Phase. Molecular Cell. 40(1):22-33.
10. Rai R, Li JM, Zheng H, Lok GT, Deng Y, Huen MS, Chen J, Jin J, Chang S. 2011. The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection. Nature Structural & Molecular Biology. 18(12):1400-1407. (The first two authors contribute this work equally)
11. Li C, Peart N, Xuan Z, Lewis DE, Xia Y, Jin J. 2014. PMA induces SnoN proteolysis and CD61 expression through an autocrine mechanism. Cell Signal. 26(7):1369-1378.
12. Maréchal A, Li JM, Ji XY, Wu CS, Yazinski SA, Nguyen HD, Liu S, Jiménez AE, Jin J, Zou L. 2014. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. Molecular Cell. 53(2):235-246.
13. Li JM, Wu H, Zhang W, Blackburn MR, Jin J. 2014. The p97-UFD1L-NPL4 protein complex mediates cytokine-induced IκBα proteolysis. Mol Cell Biol. 34(3):335-347.
14. Ha K, Ma C, Lin H, Tang L, Lian Z, Zhao F, Li JM, Zhen B, Pei H, Han S, Malumbres M, Jin J, Chen H, Zhao Y, Zhu Q, Zhang P. 2017. The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites. Nat Commun. 8:15751.
15. Song A, Zhang Y, Han L, Yegutkin GG, Liu H, Sun K, D'Alessandro A, Li J, Karmouty-Quintana H, Iriyama T, Weng T, Zhao S, Wang W, Wu H, Nemkov T, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Hansen KC, Zhang H, Bogdanov M, Dowhan W, Jin J, Kellems RE, Eltzschig HK, Blackburn M, Roach RC, Xia Y. 2017. Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent. Nat Commun. 8:14108.
16. Liu N, Zhang J, Yang X, Jiao T, Zhao X, Li W, Zhu J, Yang P, Jin J, Peng J, Li Z, Ye X. 2017. HDM2 Promotes NEDDylation of Hepatitis B Virus HBx To Enhance Its Stability and Function. J Virol. 91(16). pii: e00340-17.
17. Jin J. 2019. Interplay between ubiquitylation and SUMOylation: Empowered by phase separation. J Biol Chem. 294(42):15235-15236.
18. Li Y, Dammer EB, Gao Y, Lan Q, Villamil MA, Duong DM, Zhang C, Ping L, Lauinger L, Flick K, Xu Z, Wei W, Xing X, Chang L, Jin J, Hong X, Zhu Y, Wu J, Deng Z, He F, Kaiser P, Xu P. 2019. Proteomics Links Ubiquitin Chain Topology Change to Transcription Factor Activation. Mol Cell. 76(1):126-137.
19. Shi W, Ding R, Zhou PP, Fang Y, Wan R, Chen Y, Jin J. 2020.Coordinated Actions Between p97 and Cullin-RING Ubiquitin Ligases for Protein Degradation. Adv Exp Med Biol. 1217:61-78.
20. Wirianto M，Yang J, Kim E, Gao S; Paudel KR, Choi JM, ChoeJ, Gloston GF, Ademoji, Parakramaweera P, Jin J, Esser KA, Jung SY, Geng , YJ, Lee HK, Chen Z, Yoo SH. 2020. The GSK-3β-FBXL21 axis contributes to circadian TCAP degradation and skeletal muscle function. Cell Reports. 32(11): 108140.
21. Chen Y, Jin J. 2020. The application of ubiquitin ligases in the PROTAC drug design. Acta Biochim Biophys Sin (Shanghai). 52(7):776-790.
22. Jinquan Liu, Bo Yuan, Jin Cao, Hongjie Luo, Shuchen Gu, Mengdi Zhang, Ran Ding, Long Zhang, Fangfang Zhou, Mien-Chie Hung, Pinglong Xu, Xia Lin, Jianping Jin*, Xin-Hua Feng*, 2021, AMBRA1 promotes TGF-β signaling and breast cancer metastasis via non-proteolytic polyubiquitylation of Smad4, Cancer Research, in press (* corresponding author).
23. Li L, Mi D, Pei H, Duan Q, Wang X, Zhou W, Jin J, Li D, Liu M, Chen Y. 2020. In vivo target protein degradation induced by PROTACs based on E3 ligase DCAF15. Signal Transduct Target Ther. 5(1):129.
24. Mengjia Lin, Xiaoyun Zheng, Jianping Jin. 2022. Non-traditional translation is the key to UFMylation and beyond. J Biol Chem. 298(10) 102431 (Invited research highlight)
25.Wenbo Shi, Ran Ding, Yilin Chen, Fubo Ji, Junfang Ji, Weirui Ma, and Jianping Jin#. The HRD1-SEL1L ubiquitin ligase regulates stress granule homeostasis in couple with distinctive signaling branches of ER stress. iScience, 2024, 27(7): 110196.
26.Mengjia Lin, Xiaoyun Zheng, Jianing Yan, Fei Huang, Yinlin Chen, Ran Ding, Jinkai Wan, Lei Zhang, Chenliang Wang, Jinchang Pan, Xiaolei Cao, Kaiyi Fu, Yan Lou, Xin-Hua Feng, Junfang Ji, Bin Zhao, Fei Lan, Li Shen, Xianglei He, Yunqing Qiu#, Jianping Jin#. The RNF214-TEAD-YAP signaling axis promotes hepatocellular carcinoma progression via TEAD ubiquitylation. Nat Commun. 2024 Jun 11;15(1):4995. doi: 10.1038/s41467-024-49045-y. PubMed PMID: 38862474; PubMed Central PMCID: PMC11167002.
27.Chen Y, Xue H, Jin J. Applications of protein ubiquitylation and deubiquitylation in drug discovery. J Biol Chem. 2024;300(5):107264. doi:10.1016/j.jbc.2024.107264.