In ZJU：
· Wang B, Zhang L*, Zhou F*. Engineering biomolecular condensates for precision cancer targeting. Nature Reviews Bioengineering. 2026
· Zhang Z, Gu Y*, He H, Qiao S, Long X, Zhang L*, Zhou F*. The AMPK signaling pathway in cell metabolism and human diseases. Signal Transduction and Targeted Therapy. 2026
· Wu YR, Wu YC, Gao Z, Yu W*, Zhang L*, Zhou F*. Revitalizing T cells: breakthroughs and challenges in overcoming T cell exhaustion. Signal Transduction and Targeted Therapy. 2026
· Zhu X, Liu S*, Zhang L*. Non-canonical STING-ZBP1 signaling orchestrates a novel necroptosis pathway. Signal Transduction and Targeted Therapy. 2026
· Bian W, Zhou F*, Zhang L*. A new frontier in synthetic biology: leveraging phase separation for robust gene circuits. Science Bulletin. 2026
· Duan N, Ren J*, Zhang L*. The surprising cancer-nerve alliance drives cancer metastasis. Medicine Plus. 2026
· Su X, Yang Q, Zhang L*. MT-125 as a promising targeted therapy for glioblastoma through NMII inhibiton and ROS-mediated apoptosis. Medicine Plus. 2026
· Xu J, Bai L, Wang B, Song H, Zhang L*, Zhou F*. Liquid-liquid phase separation in viral infection and immunology. MedComm. 2026
· Wang B, Wang Y, Pan T, Zhou L, Ran Y, Zou J, Yan X, Wen Z, Lin S, Ren A, Wang F, Liu Z, Liu T, Lu H, Yang B*, Zhou F*, Zhang L*. Targeting RIG-I to regulate cytosolic RNA-sensing. Nature Cell Biology. 2025
· Zong Z, Ren J, Yang B*, Zhang L*, Zhou F*. Emerging roles of lysine lactyltransferase and lactylation. Nature Cell Biology. 2025
· Zhou F*, Zhang L*. Regulation of RIG-I activity by phase separation reveals new therapeutic opportunities. Nature Cell Biology. 2025
· Ran Y, Yang Q, Zhou L, Li H, Yang B*, Zhang L*. Protocol for label-free quantitative lysine lactylproteome profiling. STAR Protocols. 2025
· Zhu T, Chen S, et al., Zhang L*, Wu M*, Wu H*, Yang B*. Genetically encoding ε-N-methacryllysine into proteins in live cells. Nature Communications. 2025
· Wu T, Zhou H, Tian J, Zhou R, et al., Chen H*, Tang S*, Zhang L*, Yang B*. Enrichable cross-linkers for mapping direct protein interactions. Genome Biology. 2025
· Zhou X, Xie F*, Zhang L*. Tumour-immune cell interaction in cancer progression. Cancer Research. 2025
· Zong Z, Zhang L*, Zhou F*. Lactylation in cancer: advances, challenges, and future perspectives. Cancer Research. 2025
· Zhou X, Wu Y, Zhu Z, Lu C, Zhang C, Zeng L, Xie F*, Zhang L*, Zhou F*. Mucosal immune response in biology, disease prevention and treatment. Signal Transduction and Targeted Therapy. 2025
· Wan S, Zhou X, Xie F*, Zhou F*, Zhang L*. Ketogenic diet and cancer: multidimensional exploration and reseaerch. Science China Life Sciences. 2025
· Feng X, Zhao X, Zhang L*. Innovative D-peptide strategy for targeting tau fibrils in Alzheimer's disease. Science China Life Sciences. 2025
· Yang Q, Guo C, Zhang L*. The role of metabolite sensors in metabolism-immune interaction: new targets for immune modulation. Journal of Clinical and Translational Medicine. 2025
· Niu X, Wu T, Zeng L*, Lv W*, Wang F*, Zhang L*, Zhou F*. Chronic stress in cancer development and progression. Science Bulletin. 2025
· Qin Z, Zou J, Zhang L*. Unraveling the molecular mechanisms behind tight junction belt formation. Science Bulletin. 2025
· Zhou X, Zhou F*, Zhang L*. Dual inhibition of PD-1 and LAG-3: uncovering mechanisms to reverse T cell exhaustion and enhance anti-tumor immunity. Science Bulletin. 2025
· Zhang Z, Xie F*, Zhang L*. Bending and scission: when the membraneless condensates meet endosome membrane. MedComm. 2025
· Guo C, Yang Q, Zhang L*. Intercellular mitochondrial transfer enhances the antitumor immunity of CD8+ T cells. MedComm-Oncology. 2025
· Yu R, Wu Y, Zhang L*. Targeting mutant protein kinase B with lysine-selective salicylaldehyde inhibitor and Zn2+ chelation: A novel therapeutic strategy. Molecular Biomedicine. 2025
· Hu X, Wang B, Zhang L*. Metformin modulates mitochondrial metabolism and epigenetic dysregulation in DNMT3A-mutated clones. Molecular Biomedicine. 2025
· Zhu X, Wang Y, Zhang L*. Combined inhibition of protein kinase B and enhancer of zeste homolog 2: a novel strategy to induce triple-negative cancer cell death. Molecular Biomedicine. 2025
· Wu Y, Gao Z, Zhang L*. Lithocholic acid activates TULP3-Sirtuin-v-ATPase-AMPK axis to enhance longevity. MedComm-Future Medcine. 2025
· Gu Y, He H, Qiao S, Shao Y, Wang L, Zhang Z*, Zhang L*, Zhou F*. EGFR: new insights on its activation and mutation in tumour and tumour immunotherapy. Advanced Science. 2025
· Zhu F, Fu H, Zhu W, Li C, et al., Huang J, Zhang L, Xue Y*, Lu H*. Stabilization of AFF1 by PARylation ensures transcriptional restart after DNA damage. Nature Chemical Biology. 2025
· Li G, Du T, Wang J, Jie K, Ren Z, Zhang X, Zhang L, Wu S*, Ru H*. Structural insights into the RNA-dependent RNA polymerase complexes from highly pathogenic marburg and Ebola viruses. Nature Communications. 2025
· Zhu M, Zhou S, Zhang Y, Chen Q, Yuan X, Zhang L, Yan H*, Wang F*. The cAMP-PKA signaling initiates mitosis by phosphorylating Bora. Nature Communications. 2025
· Li H, Liu C, Li R, Zhou L, Ran Y, Yang Q, Huang H, Lu H, Song H, Yang B, Ru H, Lin S, Zhang L*. AARS1 and AARS2 senses L-lactate to regulate cGAS as global lysine lactyltransferase. Nature. 2024
· Zou J, Qin Z, Li R*, Yan X, Huang H, Yang B, Zhou F*, Zhang L*. iProPhos: a web-based interactive plastform for integrated proteome and phosphoproteome analysis. Molecular & Cellular Proteomics. 2024
· Ren J, Wang S, Zong Z, Pan T, Liu S, Mao W, Huang H, Yan X, Yang B, He X, Zhou F*, Zhang L*. TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence. Nature Commaunications. 2024
· Yuan X, Yan L, Chen Q, Zhu S, Zhou X, Zeng L, Liu M, He X, Huang J, Lu W, Zhang L*, Yan H*, Wang F*. Molecular mechanism and functional significance of Wapl interaction with the Cohesin complex. Proceedings of the National Academy of Sciences (PNAS). 2024
· Liu S, Ren J, Hu Y, Zhou F*, Zhang L*. TGF-β family signaling in human stem cell self-renewal and differentiation. Cell Regeneration. 2024
· Ren J, Liu S, Zhang L*. Inhibitor of differentiation 3 (ID3) confers the robust anti-tumor activity of Kupffer cells. MedComm. 2024
· Bai L, Zhou F*, Zhang L*. Booster vaccination: host preparation against omicron challenge by innate immunity training. MedComm. 2024
· Guo H, Zhou F*, Zhang L*. Nε-Acetyl-Nε-methyllysine: a new post-translational modification to mark chromatin. MedComm-Future Medicine. 2024
· Bai L, Zhou F*, Zhang L*. Serotonin signaling: a new player and therapeutic target beyond long-haul coronavirus disease. MedComm. 2024
· Wei X, Zhou F*, Zhang L*. PARP1-DNA co-condensation: the driver of broken DNA repair. Signal Transduction and Targeted Therapy. 2024
· Zou J, Qin Z, Zhang L*. High-resolution spatiotemporal mapping: a comprehensive view of eukaryotic cell cycle proteome dynamics. Signal Transduction and Targeted Therapy. 2024
· Gu Y, Zhou X, Zhang L*. Advances in the elucidation of CircRNA translocation. MedComm-Future Medicine. 2024
· Bai L, Xu J, Zeng L*, Zhang L*, Zhou F*. A review of HSV pathogenesis, vaccine development, and advanced applications. Molecular Biomedicine. 2024
· Zhang M, Li J, Liu S, Zhou F*, Zhang L*. UCHL5 is a putative prognostic marker in renal cell carcinoma: a study of UCHL family. Molecular Biomedicine. 2024
· Gu Y, Zhang L*, Lu W*. Advancing clinical-basic-clinical research: exploring novel immunotargets for ovarian cancer. Signal Transduction and Targeted Therapy. 2024
· Shang Y, Shu X, Lu Y, Zhu W, Li R, Fu H, Li C, Sun W, Li Z, Zhang Y, Cao X, Ye X, Emmanuel A, Zhao B, Zhang L, Wu H, Feng XH, Yang B, Lu H. A chaperon-like function of FUS ensures TAZ condensate dynamics and transcriptional activation. Nature Cell Biology. 2024
· Ding W, Liu C, Chen Y, Gu J, Fang C, Hu L, Zhang L, Yuan Y, Feng XH, Lin S. Computational design and genetic incorporation of lipidation mimics in living cells. Nature Chemical Biology. 2024
· Yan L, Yuan X, Liu M, Chen Q, Zhang M, Xu J, Zeng LH, Zhang L, Huang J, Lu W, He X, Yan H, Wang F. A non-canonical role of the inner kinetochore in regulating siter-chromatid cohesion at centromeres. EMBO Journal. 2024
· Liu D, Ding W, Cheng J, Wei Q, Lin Y, Zhu T, Tian J, Sun K, Zhang L, Lu P, Yang F, Liu C, Tang S, Yang B. Characterize direct protein interactions with enrichable, cleavable and latent bioreactive unnatural amino acids. Nature Communications. 2024
· Tan L, Yan M, Su Z, Wang H, Li H, Zhao X, Liu S, Zhong L, Sun Q, Lu D. R-spondin-1 induces Axin degradation via the LRP6-CK1e axis. Cell Communication and Signaling. 2024
· Dong X, Lin Y, Li K, Liang G, Huang X, Pan J, Wang L, Zhang D, Liu T, Wang T, Yan X, Zhang L, Li X, Qu X, Jia D, Li Y, Zhang H. Consensus statement on extracellular vesicles in liquid biopsy for advancing laboratory medicine. Clinical Chemistry and Laboratory Medicine. 2024
· Dai T, Zhang L, Ran Y, Zhang M, Yang B, Lu H, Liu J, Lin S*, Zhang L*, Zhou F*. DeSUMOylation by SENP1 inhibits MAVS aggregation and antagonizes IRF3 activation. Nature Structural & Molecular Biology. 2023
· Liu S, Ren J, Zhang L*. RHOJ: a key regulator of EMT-associated resistance to chemotherapy. Signal Transduction and Targeted Therapy. 2023
· Pan C, Zhou F*, Zhang L*. The loss of epigenetic information: not only consequences but a cause of mammalian aging. Signal Transduction and Targeted Therapy. 2023
· Li R, Zou J, Pei D, Pan T, Yang B, Liu X, Chen Y*, Zhou F*, Zhang L*. Deciphering dynamic changes of the aging transcriptome with COVID-19 progression and convalescence in the human blood. Signal Transduction and Targeted Therapy. 2023
· Z Zong, Zhou F*, Zhang L*. The fungal mycobiome: a new hallmark of cancer revealed by pan-cancer analyses. Signal Transduction and Targeted Therapy. 2023
· Su P, Zhou F*, Zhang L*. Motile cilia and microvillar: accomplices of SARS-CoV-2 in penetrating mucus barrier and infecting airway epithelium. Signal Transduction and Targeted Therapy. 2023
· Gao Z, Wang B, Zhang L*. Activated STING: an icon channel to trigger non-interferon-related functions. Signal Transduction and Targeted Therapy. 2023
· Yang Q, Wang B, Zheng Q, Li H, Meng X*, Zhou F*, Zhang L*. A review of gut microbiota-derived metabolites in tumor progression and cancer therapy. Advanced Science. 2023
· Su P, Wu Y, Xie F, Zeng Q, Chen L, Liu Z, Meng X*, Zhou F*, Zhang L*. A review of extracellular vesicles in COVID-19 diagnosis, treatment and prevention. Advanced Science. 2023
· Ren J, Yu P, Liu S, Li R, Niu X, Chen Y, Zhang Z*, Zhou F*, Zhang L*. Deubiquitylating enzymes in cancer and immunity. Advanced Science. 2023
· Lan T, Zhou F*, Zhang L*. WNK1, a molecular crowding sensor, links phase separation to cellular physiological stress. MedComm. 2023
· Kuang Y, Sun W, Zhang L*. The presence of Y chromosome leads to the difference of cancer in patients with different sexes. MedComm. 2023
· Yang Q, Zhang L*, Chen J*. Lactate, a critical regulator of cell proliferation via anaphase promoting complex remodeling. MedComm-Oncology. 2023
· Tu Y, Zhou F*, Zhang L*. SIK3-HDAC4 signaling pathway: the swith for transition between sleep and wakefulness. Molecular Biomedicine. 2023
· Yao Y, Zong Z, Zhang L*. Unlocking γδ T cell power: pathways that boost cancer defense. Molecular Biomedicine. 2023
· Niu X, Zhou F*, Zhang L*. Microglia regulate the health of central nervous system through myelin. Molecular Biomedicine. 2023
· Pan C, Xiao Z, Wu C, Zhang L*, Jia J*, Zhen M*. A new method to synthesize multiple gRNA libraries and functional mapping of mammalian H3K4me3 regions. Nucleic Acids Research. 2023
· Guan J, Zhang L*, Zhou F*. TBK1: a new target for overcoming cancer immunotherapy resistance. Science China Life Sciences. 2023
· Wu T, Li S, Ran Y, Lin Y, Liu L, Zhang X, Zhou L, Zhang L, Wu D, Yang B, Tang S. Mapping protein direct interactome of oxidoreductases with small molecular chemical cross-linkers in live cells. Redox Biology. 2023
· Niu X, Zhang L, Wu Y, Zong Z, Wang B, Liu J*, Zhang L*, Zhou F*. Biomolecular condensates: formation mechanisms, biological functions and therapeutic targets. MedComm. 2023
· Zhou F*, Zhang L*. IRF3 and IRF7 require SIRT1 for LLPS and transactivation of IFN-I. Nature Immunology. 2022
· Xie F, Zhou X, Li H, Su P, Liu S, Li R, Zou J, Wei X, Pan C, Zhang Z, Zheng M, Liu Z, Meng X, Ovaa H, Ten Dijke P*, Zhou F*, Zhang L*. USP8 promotes cancer progression and extracellular-vesicle mediated CD8+ T cell exhaustion by deubiquitinating TGF-β receptor TβRII. EMBO Journal. 2022
· Wang S, Chu F, Xia R, Guan J, Zhou L, Fang X, Dai T, Xie F, Zhang L* and Zhou F*. LPA Maintains Innate Antiviral Immunity in a pro-active state via STK38L-Mediated IRF3 Ser303 Phosphorylation. Cell Reports. 2022
· Fang X, Zhang L*. ZBP1 contributes to interferonopathies caused by impaired ADAR1 function. Molecular Biomedicine. 2022
· Guan J，Zhang L*, Zhou F*. PI3K-PANK4: a new target for de novo synthesis of coenzyme A. Molecular Biomedicine. 2022
· Wang B, Zhang L, Zhou F*. Zhang L*. Potential mechanisms by which impaired ketogenesis links metabolism to T-cell dysfunction in patients with severe COVID-19. Medcomm. 2022
· Wei X, Xie F, Zhou X, Yan H, Liu T, Huang J*, Wang F*, Zhou F*, Zhang L*. Developments in the understanding of pyroptosis and its potential role in the treatment of inflammation and cancer. Cellular & Molecular Immunology. 2022
· Su P, Zhang L, Zhou F*, Zhang L*. Circular RNA vaccine, a novel mRNA vaccine design strategy for SARS-COV-2 and variants. MedComm. 2022
· Li J, Zhang M, Ma W, Yang B, Lu H, Zhou F*, Zhang L*. Post-translational modifications in liquid-liquid phase separation：A comprehensive review. Molecular Biomedicine. 2022
· Zhao L, Zhou X, Xie F, Zhang L, Yan H, Huang J, Zhang C*, Zhou F*, Chen J*, Zhang L*. Ferroptosis in cancer and cancer immunotherapy. Cancer Communications. 2022
· Wang Y, Zhou F*, Zhang L*. Cuprotosis: A new form of programmed cell death. Cellular & Molecular Immunology. 2022
· Li H, Zhou F*, Zhang L*. STING, a critical contributor to SARS-CoV-2 immunopathology. Signal Transduction and Targeted Therapy. 2022
· Qin Z, Zhou F*, Zhang L*. Novel pyroptosis-independent functions of gasdermins. Signal Transduction and Targeted Therapy. 2022
· Wang B, Zhang L, Wang Y, Dai T, Qin Z, Zhou F, Zhang L*. Alteration in microbiota of Patients with COVID-19: Potential mechanisms and therapeutic interventions. Signal Transduction and Targeted Therapy. 2022
· Ren J，Zhang Z, Zong Z, Zhang L*, Zhou F*. Emerging implications of phase separation in cancer. Advanced Science. 2022
· Pei D, Zhang L*, Zhang Z*. Tumor–neuron interactions: a novel concept contributor to glioblastoma invasion. MedComm-Oncology. 2022
· Wang Y，Fang X, Wang S, Wang B, Chu F, Zhang L*, Zhou F*. The role of O-GlcNAcylation in innate immunity and inflammation. Journal of Molecular Cell Biology. 2022
· Xie Y，Xie F, Zhou X，Zhang L, Yang B, Huang J, Wang F, Yan H, Zeng L*, Zhang L*, Zhou F*. Microbiota in tumors: from understanding to application. Advanced Science. 2022
· Tu Y, Fang P, Zhang L*, Sun K*. Analysis of the effect of Snai family in breast cancer and immune cell. Front. Cell Dev. Biol. 2022
· Fan Y, Xiang Li, Zhang L, Wan S*, Zhang L*, Zhou F*. SARS-CoV-2 Omicron variant: rencent progress and future perspectives. Signal Transduction and Targeted Therapy. 2022
· Fan Y, Li X, Zhang L, Zhang L*, Zhou F*. SUMOylation in viral replication and antiviral defense. Advanced Science. 2022
· Editorial: TGF-β and BMP signaling in cancer. Yan X, Zhang L, Miyazawa K, Ten Dijke P. Front. Cell Dev. Biol. 2022
· Zheng L, Liu J, Niu L, Mohammad K, Yang A, Arttu J, Dai Q, Timothy R, Dinshaw J, Zhang L, Supriya G, Yang Y, Ren A, Eric C. Distinct structural bases for sequence-specific DNA binding by mammalian BEN domain proteins. Genes & development. 2022
· Yao T, Wang S, Zhang L, Johnson L, Zhou F*. Opsonizing antibodies mediated SARS-CoV-2 entry into monocytes leads to inflammation. MedComm-Future Medicine. 2022
· Huang Y, Liu S, Shan M et al., Zhang L, Li D, Ten Dijke P. RNF12 is regulated by AKT phosphorylation and promotes TGF-β driven breast cancer metastasis. Cell Death Disease. 2022
· Lyengar PV, Marvin DL, Lama D, Tan TZ, Suriyamurthy S, Xie F, van Dinther M, Mei H, Verma CS, Zhang L, Ritsma L, Ten Dijke P. TRAF4 inhibits bladder cancer progression by promoting BMP/SMAD signaling. Molecular Cancer Research. 2022
· Xie F, Su P, Pan T, Zhou X, Li H, Huang H, Wang A, Wang F, Huang J, Yan H, Zeng LH, Zhang L*, Zhou F*. Engineering extracellular vesicles enriched with palmitoylated ACE2 as COVID-19 therapy. Advanced Materials. 2021
· Li H, Zhou F*, Zhang L*. ADP-riboxanation-A new pyroptosis evasion strategy. Journal of Molecular Cell Biology. 2021
· Dong Y, Dai T, Wang B, Zhang L, Zeng L, Huang J, Yan H, Zhang L*, Zhou F*. The way of SARS-CoV-2 vaccine development: sucess and challenges. Signal Transduction and Targeted Therapy. 2021
· Fan Y, Zhang L*, Zhou F*. cGAS-like receptors: new RNA sensors in Drosophila. Signal Transduction and Targeted Therapy. 2021
· Jin K, Zhou F, Zhang L*. Cancer Environment Immunotherapy: targeting TGF-β finds its way towards tissue healing and vasculature remodeling. Signal Transduction and Targeted Therapy. 2021
· Xie Y, Xie F, Zhang L, Zhou X, Huang J, Wang F, Jin J, Zhang L*, Zeng L*, Zhou F*. Targeted anti-tumor immunotherapy using tumor infiltrating cells. Advanced Science. 2021
· Wang B, Zhang L, Dai T, Qin Z, Lu H, Zhang L*, Zhou F*. Liquid-liquid phase separation in human health and diseases. Signal Transduction and Targeted Therapy. 2021
· Chen Q, Zhang M, Pan X, Yuan X, Zhou L, Yan L, Zeng L, Xu J, Yang B, Zhang L, Huang J, Lu W, Fukagawa T, Wang F, Yan H. Bub1 and CENP-U redundantly recruit Plk1 to stabilize kinetochore-microtubule attachments and ensure acurate chromosome segregation. Cell Reports. 2021
· Liu S, Gonzalez-Prieto R, Zhang M, Geurink PP, Kooij R, Lyengar PV, van Dinther M, Bos E, Zhang X, Le Devedec SE, van de Water B, Koning RI, Zhu HJ, Mesker WE, Vertegaal ACO, Ovaa H, Zhang L, Martens JWM, Ten Dijke P. Deubiquitinase activity profiling identifies UCHL1 as a candidate oncoprotein that promotes TGF-β-induced breast cancer metastasis. Clinical Cancer Research. 2020
· Zhang Z, Fang X, Wu X, Chu F, Ling L, Li J, Wang S, Zang J, Zhang B, Ye S, Zhang L, Yang B, Lin S, Huang H, Wang A, Zhou F. Acetylation-dependent deubiquitinase OTUD3 controls MAVS activation in innate antiviral immunity. Molecular Cell. 2020
· Li T, Wu B, Yang T, Zhang L, Jin K. The outstanding antitumor capacity of CD4+ T helper lymphocytes. BBA-Reviews on Cancer. 2020
· Dong Y, Dai T, Zhang L, Zhou F. Coronavirus in continuous flux: from SARS-CoV to SARS-CoV-2. Advanced Science. 2020
· Fan KQ, Li YY, Wang HL, Mao XT, Guo JX, Wang F, Huang LJ, Li YN, Ma XY, Gao ZJ, Chen W, Qian DD, Xue WJ, Cao Q, Zhang L, Shen L, Zhang L, Tong C, Zhong JY, Lu W, Lu L, Ren KM, Zhong G, Wang Y, Tang M, Feng XH, Chai RJ, Jin J. Stress-Induced Metabolic Disorder in Peripheral CD4+ T cells leads to Anxiety-like Behavior. Cell. 2019
· Zhang Z, Du J, Wang S, Shao L, Jin K, Li F, Wei B, Ding W, Fu P, van Dam H, Wang A, Jin J, Ding C, Yang B, Zheng M, Feng XH, Guan KL, Zhang L*. OTUB2 promotes cancer metastasis via Hippo independent activation of YAP and TAZ. Molecular Cell. 2019
· Dai T, Wu L, Wang S, Wang J, Xie F, Zhang Z, Fang X, Li J, Fang P, Li F, Jin K, Dai J, Yang B, Zhou F, van Dam H, Cai D, Huang H, Zhang L*. FAF1 regulates antiviral immunity by inhibiting MAVS but is antagonized by phosphorylation upon viral infection. Cell Host & Microbe. 2018
· Gao L, Wang L, Dai T, Jin K, Zhang Z, et al., Zhou F*, Zhang L*. Tumor-derived exosome antagonize innate antiviral immunity. Nature Immunology. 2018
· Zhang M, Jin K, Gao L, Zhang Z, Li F, Zhou F*, Zhang L*. Methods and technologies for exosome isolation and characterization. Small Methods. 2018
· Yan X*, Zhang L*. A special issue on TGF-β signaling: regulation, crosstalk and biology. Acta Biochim Biophy Sin. 2018
· Wang S, Xie F, Chu F, Zhang Z, Yang B, Dai T, Gao L, Wang L, Ling L, Jia J, van Dam H, Jin J, Zhang L*, Zhou F*. YAP antagonizes innate antiviral immunity and is targeted for lysosomal degradation through kinase-IKKe mediated phosphorylation. Nature Immunology. 2017
· Zhang Z, Fan Y, Xie F, Shao L, et al., Jin J, Ding C, Sheng Y, Zhou F, Zhang L*. Breast cancer metastasis suppressor OTUD1 deubiquitylates SMAD7. Nature Communications. 2017
· Xie F, Jin K, Shao L, Fan Y, Tu YF, Yang B, van Dam H, Ten Dijke P, Weng HL, Dooley S, Wang S, Jia JL, Jin J, Zhou F*, Zhang L*. FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis. Nature Communications. 2017
· Zhou F, Xie F, Jin K, Zhang ZK, Clerici M, Gao R, Sixma TK, Huang HZ, van Dinther M, Zhang L*, Ten Dijke P*. USP4 inhibits SMAD4 monoubiquitination and promotes activin and BMP signaling. EMBO Journal. 2017
· Jin K*, Li T, van Dam H, Zhou F*, Zhang L*. Molecular insight into tumor metastasis: tracing the dominant events. Journal of Pathology. 2017
· Xie F, Ling L, van Dam H, Zhou F*, Zhang L*. TGF-β signaling in cancer metastasis. Acta Biochim Biophy Sin. 2017
· Zhang L*, Xie F, Ten Dijke P,Zhang J,Zhou F*. SUMO-triggered ubiquitination of NR4A1 controls macrophage cell death. Cell Death & Differentiation. 2017
· Zhou F*, Li F, Fang PF, Dai T, Yang B, van Dam H, Jia jl, Zheng M, Zhang L*. Ubiquitin-specific Protease 4 Antagonize Osteoblast Differentiation through Dishevelled. J Bone Miner Res. 2016
· Jin K*, Li T, Sanchez-Duffhues G, Zhou F*, Zhang L*. Involvement of inflammation and its related microRNAs in hepatocellular carcinoma. Oncotarget. 2016
· Xie F, Zhang Z, van Dam H, Zhang L*, Zhou F*. Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination. Cells. 2014
· Zhou F, Li F, Xie F, Zhang Z, Huang H, Zhang L*. TRAF4 mediates activation of TGF-β signaling and is a biomarker for oncogenesis in breast cancer. Sci China Life Sci. 2014
· Zhang J, Zhang X, Xie F, Zhang Z, van Dam H, Zhang L*, Zhou F*. The regulation of TGF-β/SMAD signaling by protein deubiquitination. Protein Cell. 2014
· Zhou F, Drabsch Y, Dekker TJ, de Vinuesa AG, Li Y, Hawinkels LJ, Sheppard KA, Goumans MJ, Luwor RB, de Vries CJ, Mesker WE, Tollenaar RA, Devilee P, Lu CX, Zhu H, Zhang L*, Dijke PT*. Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-β signalling. Nature Communications. 2014
· Zhang L*, Zhou F*, Ten Dijke P*. Signaling interplay between TGF-β receptor and PI3K/AKT pathway in cancer. Trends in Biochemical Sciences. 2013
In LUMC:
· Zhang L#, Zhou F#, García de Vinuesa A, de Kruijf EM, Mesker WE, Hui L, Drabsch Y, Li Y, Bauer A, Rousseau A, Sheppard KA, Mickanin C, Kuppen PJ, Lu CX, Ten Dijke P. TRAF4 Promotes TGF-β Receptor Signaling and Drives Breast Cancer Metastasis. Molecular Cell. 2013 Sep
· Zhang L#, Zhou F#, Drabsch Y, Snaar-Jagalska E, Mickanin C, Huang H, Sheppard KA, Lu C, and ten Dijke P. USP4 is regulated by Akt phosphorylation and directly deubiquitinates TGF-βtype I receptor. Nature Cell Biology. 2012
· Zhang L#*, Huang H#, Zhou F#, Pardo CG, Zhang T, Barakat TS, Sheppard KA, van Dam H, Gribnau J, Lu C, and ten Dijke P*. RNF12 controls embryonic stem cell fate and morphogenesis in zebrafish embryos by targeting Smad7 for degradation. Molecular Cell. 2012;
· Zhang L#, Zhou F#, Li Y, Drabsch Y, Zhang J, van Dam H, Ten Dijke P.Fas-associated factor 1 is a scaffold protein that promotes β-TrCP mediated β-catenin ubiquitination and degradation. J Biol Chem. 2012;
· Gong K, Zhou F, Huang HZ, Gong YD, Zhang L*. Suppression of GSK3β by ERK mediates lipopolysaccharide induced cell migration in macrophage through β-catenin signaling. Protein Cell. 2012;
· Zhou F#, Zhang L#*, van Laar T, van Dam H, ten Dijke P*. GSK3β inactivation induces apoptosis of leukemia cells by repressing the function of c-Myb. Mol Biol Cell. 2011;
· Zhou F, Zhang XF, van Dam H, ten Dijke P, Huang HZ*, Zhang L*.Ubiquitin-specific protease 4 mitigates Toll-like/Interleukin-1 receptor signaling and regulates innate immune activation. J Biol Chem. 2012;
· Zhou F, van Laar T, Huang HZ, Zhang L*. APP and APLP1 are degradated through autophagy in response to proteasome inhibition in neuronal cells. Protein Cell. 2011;
· Zhou F; Gong K; van Laar T; Gong Y, Zhang L*. Wnt/β-catenin signal pathway stabilizes APP intracellular domain (AICD) and promotes its transcriptional activity. Biochem Biophys Res Commun. 2011;
In Tsinghua:
· Zhou F#, Zhang L#, Gong K, Lu G, Sheng B, Wang A, Zhao N, Zhang X, Gong Y. LEF-1 activates the transcription of E2F1. Biochem Biophys Res Commun. 2008
· Zhou F#, Zhang L#, Wang A, Song B, Gong K, Zhang L, Hu M, Zhang X, Zhao N, Gong. The association of GSK3β with E2F1 facilitates nerve growth factor-induced neural cell differentiation. J Biol Chem. 2008
· Zhang L, Gao X, Wen J, Ning Y, Chen YG. Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation. J Biol Chem. 2006;
· Zhang L, Zhou H, Su Y, Sun Z, Zhang H, Zhang L, Zhang Y, Ning Y, Chen YG, Meng A. Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors. Science. 2004;